ALCAM

CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene.[4][5] It is also called CD166 (cluster of differentiation 166), MEMD,[6] SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat.

ALCAM
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesALCAM, CD166, MEMD, activated leukocyte cell adhesion molecule
External IDsOMIM: 601662 MGI: 1313266 HomoloGene: 1229 GeneCards: ALCAM
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q13.11Start105,366,909 bp[1]
End105,576,900 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

214

11658

Ensembl

ENSG00000170017

n/a

UniProt

Q13740

Q61490

RefSeq (mRNA)

NM_001627
NM_001243280
NM_001243281
NM_001243283

NM_009655
NM_001331110

RefSeq (protein)

NP_001230209
NP_001230210
NP_001230212
NP_001618

NP_001318039
NP_033785

Location (UCSC)Chr 3: 105.37 – 105.58 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Some literature sources have also cited it as the CD6 ligand (CD6L). It is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, neurons, melanoma cells, and also in sweat and sebaceous glands. CD166 protein expression is reported to be upregulated in a cell line deriving from a metastasizing melanoma.[6] CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development.

Recently, CD166 has also been used as a potential cancer stem cell marker.


References

  1. GRCh38: Ensembl release 89: ENSG00000170017 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U, et al. (Jun 1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J Exp Med. 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054. PMID 7760007.
  5. "Entrez Gene: ALCAM activated leukocyte cell adhesion molecule".
  6. Degen WG, van Kempen LC, Gijzen EG, et al. (1998). "MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule)". Am. J. Pathol. 152 (3): 805–13. PMC 1858405. PMID 9502422.

Further reading



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