ADP-specific glucokinase

In enzymology, an ADP-specific glucokinase (EC 2.7.1.147) also known as ADP-dependent glucokinase is an enzyme that catalyzes the chemical reaction

ADP + D-glucose AMP + D-glucose 6-phosphate
ADP-specific glucokinase
Identifiers
EC number2.7.1.147
CAS number173585-07-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
ADPGK
Identifiers
AliasesADPGK, 2610017G09Rik, ADP-GK, ADP-specific glucokinase, ADP-dependent glucokinase, ADP dependent glucokinase
External IDsOMIM: 611861 MGI: 1919391 HomoloGene: 41739 GeneCards: ADPGK
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q24.1Start72,751,369 bp[1]
End72,785,846 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

83440

72141

Ensembl

ENSG00000159322

ENSMUSG00000025236

UniProt

Q9BRR6

Q8VDL4

RefSeq (mRNA)

NM_028121
NM_001359282

RefSeq (protein)

NP_082397
NP_001346211

Location (UCSC)Chr 15: 72.75 – 72.79 MbChr 9: 59.29 – 59.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thus, the two substrates of this enzyme are ADP and D-glucose, whereas its two products are AMP and D-glucose 6-phosphate.

This enzyme belongs to the family of transferases, to be specific those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor.

In humans, the ADP-dependent glucokinase is encoded by the ADPGK gene.[5]

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1GC5.

gollark: Well, yes, much of the UK's governance is fairly bees?
gollark: Yes, this is quite uncool.
gollark: What if we make it so that you can appoint lords much more easily, but they can only vote on one thing before they have to resign?
gollark: Fascinating.
gollark: I thought they stopped hereditary peerages from hereditating.

References

  1. GRCh38: Ensembl release 89: ENSG00000159322 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025236 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ronimus RS, Morgan HW (Mar 2004). "Cloning and biochemical characterization of a novel mouse ADP-dependent glucokinase". Biochemical and Biophysical Research Communications. 315 (3): 652–8. doi:10.1016/j.bbrc.2004.01.103. PMID 14975750.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.