2,8-Dihydroxyhexahydrochrysene

2,8-Dihydroxyhexahydrochrysene (2,8-DHHHC) is a synthetic, nonsteroidal weak estrogen with approximately 1/2,000th the estrogenic potency of the structurally-related estrogen diethylstilbestrol.[1][2][3] It is said to be intermediate in structure between estradiol and hexestrol, but conversely to both of them, is drastically less potent in comparison.[3]

2,8-Dihydroxyhexahydrochrysene
Clinical data
ATC code
  • None
Chemical and physical data
FormulaC18H18O2
Molar mass266.340 g·mol−1

See also

References
  1. Philipp Y. Maximov; Russell E. McDaniel; V. Craig Jordan (23 July 2013). Tamoxifen: Pioneering Medicine in Breast Cancer. Springer Science & Business Media. pp. 4–. ISBN 978-3-0348-0664-0.
  2. Virgil Craig Jordan (1986). Estrogen/antiestrogen Action and Breast Cancer Therapy. Univ of Wisconsin Press. pp. 22–. ISBN 978-0-299-10480-1.
  3. Wilds, A. L.; Sutton, Reid E. (1951). "Cyclic Analogs of Hexestrol in the Chrysene Series". The Journal of Organic Chemistry. 16 (9): 1371–1379. doi:10.1021/jo50003a006. ISSN 0022-3263.


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