CD84

CD84 (Cluster of Differentiation 84) is a human protein encoded by the CD84 gene.[5]

CD84
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PKD
Identifiers
Aliases	CD84, LY9B, SLAMF5, hmCD84 molecule
External IDs	OMIM: 604513 MGI: 1336885 HomoloGene: 48249 GeneCards: CD84
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 160,541,095 bp[1] End 160,579,516 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.54 cM Start 171,839,697 bp[2] End 171,890,718 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • identical protein binding Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane Biological process • negative regulation of granulocyte macrophage colony-stimulating factor production • defense response • innate immune system • negative regulation of interleukin-18 production • cell adhesion • adaptive immune response • negative regulation of mast cell degranulation • regulation of store-operated calcium entry • negative regulation of mast cell activation • leukocyte migration • homophilic cell adhesion via plasma membrane adhesion molecules • immune system process • autophagy Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8832	12523
Ensembl	ENSG00000066294	ENSMUSG00000038147
UniProt	Q9UIB8	Q18PI6
RefSeq (mRNA)	NM_001184879 NM_001184881 NM_001184882 NM_003874 NM_001330742	NM_001252472 NM_001289470 NM_013489
RefSeq (protein)	NP_001171808 NP_001171810 NP_001171811 NP_001317671 NP_003865	NP_001239401 NP_001276399 NP_038517
Location (UCSC)	Chr 1: 160.54 – 160.58 Mb	Chr 1: 171.84 – 171.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Members of the CD2 (see MIM 186990) subgroup of the Ig superfamily, such as CD84, have similar patterns of conserved disulfide bonds and function in adhesion interactions between T lymphocytes and accessory cells.[5]

Interactions

CD84 has been shown to interact with SH2D1A.[6][7][8][9]

See also

• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000066294 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038147 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CD84 CD84 molecule".
6. Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (Sep 2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". Journal of Immunology. 171 (5): 2485–95. doi:10.4049/jimmunol.171.5.2485. PMID 12928397.
7. Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood. 97 (12): 3867–74. doi:10.1182/blood.V97.12.3867. PMID 11389028.
8. Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (Jun 2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2". European Journal of Immunology. 32 (6): 1640–9. doi:10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S. PMID 12115647.
9. Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients" (PDF). The Journal of Biological Chemistry. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068.

Further reading

• Andreesen R, Bross KJ, Osterholz J, Emmrich F (May 1986). "Human macrophage maturation and heterogeneity: analysis with a newly generated set of monoclonal antibodies to differentiation antigens". Blood. 67 (5): 1257–64. PMID 3008886.
• Kingsmore SF, Souryal CA, Watson ML, Patel DD, Seldin MF (1995). "Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1". Immunogenetics. 42 (1): 59–62. doi:10.1007/BF00164988. PMID 7797269.
• de la Fuente MA, Pizcueta P, Nadal M, Bosch J, Engel P (Sep 1997). "CD84 leukocyte antigen is a new member of the Ig superfamily". Blood. 90 (6): 2398–405. PMID 9310491.
• Krause SW, Rehli M, Heinz S, Ebner R, Andreesen R (Mar 2000). "Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84". The Biochemical Journal. 346 Pt 3 (3): 729–36. doi:10.1042/0264-6021:3460729. PMC 1220906. PMID 10698700.
• Palou E, Pirotto F, Solé J, Freed JH, Peral B, Vilardell C, Vilella R, Vives J, Gayá A (Feb 2000). "Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains". Tissue Antigens. 55 (2): 118–27. doi:10.1034/j.1399-0039.2000.550203.x. PMID 10746783.
• Lucas AD, Chadwick N, Warren BF, Jewell DP, Gordon S, Powrie F, Greaves DR (Mar 2001). "The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo". The American Journal of Pathology. 158 (3): 855–66. doi:10.1016/S0002-9440(10)64034-5. PMC 1850344. PMID 11238035.
• Shlapatska LM, Mikhalap SV, Berdova AG, Zelensky OM, Yun TJ, Nichols KE, Clark EA, Sidorenko SP (May 2001). "CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A". Journal of Immunology. 166 (9): 5480–7. doi:10.4049/jimmunol.166.9.5480. PMID 11313386.
• Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood. 97 (12): 3867–74. doi:10.1182/blood.V97.12.3867. PMID 11389028.
• Lewis J, Eiben LJ, Nelson DL, Cohen JI, Nichols KE, Ochs HD, Notarangelo LD, Duckett CS (Jul 2001). "Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family". Clinical Immunology. 100 (1): 15–23. doi:10.1006/clim.2001.5035. PMID 11414741.
• Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients" (PDF). The Journal of Biological Chemistry. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068.
• Martin M, Romero X, de la Fuente MA, Tovar V, Zapater N, Esplugues E, Pizcueta P, Bosch J, Engel P (Oct 2001). "CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1". Journal of Immunology. 167 (7): 3668–76. doi:10.4049/jimmunol.167.7.3668. PMID 11564780.
• Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C (Nov 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". The EMBO Journal. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425.
• Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (Jun 2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2". European Journal of Immunology. 32 (6): 1640–9. doi:10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S. PMID 12115647.
• Del Valle JM, Engel P, Martín M (May 2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)". The Journal of Biological Chemistry. 278 (19): 17430–7. doi:10.1074/jbc.M301569200. PMID 12621057.
• Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (Sep 2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". Journal of Immunology. 171 (5): 2485–95. doi:10.4049/jimmunol.171.5.2485. PMID 12928397.
• Zaiss M, Hirtreiter C, Rehli M, Rehm A, Kunz-Schughart LA, Andreesen R, Hennemann B (Sep 2003). "CD84 expression on human hematopoietic progenitor cells". Experimental Hematology. 31 (9): 798–805. doi:10.1016/S0301-472X(03)00187-5. PMID 12962726.
• Romero X, Benítez D, March S, Vilella R, Miralpeix M, Engel P (Aug 2004). "Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4)". Tissue Antigens. 64 (2): 132–44. doi:10.1111/j.1399-0039.2004.00247.x. PMID 15245368.
• Nanda N, Andre P, Bao M, Clauser K, Deguzman F, Howie D, Conley PB, Terhorst C, Phillips DR (Nov 2005). "Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling". Blood. 106 (9): 3028–34. doi:10.1182/blood-2005-01-0333. PMID 16037392.

External links

• CD84+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CD84 genome location and CD84 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.