NCR2

Natural cytotoxicity triggering receptor 2 is a protein that in humans is encoded by the NCR2 gene.[3][4] NCR2 has also been designated as CD336 (cluster of differentiation 336), NKp44, NKP44; NK-p44, LY95, and dJ149M18.1.[5]

NCR2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1HKF
Identifiers
Aliases	NCR2, CD336, LY95, NK-p44, NKP44, dJ149M18.1, natural cytotoxicity triggering receptor 2
External IDs	OMIM: 604531 HomoloGene: 130365 GeneCards: NCR2
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 41,335,608 bp[1] End 41,350,889 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transmembrane signaling receptor activity • GO:0001948 protein binding • signaling receptor activity Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane • cell surface Biological process • cellular defense response • innate immune system • signal transduction • regulation of immune response • regulation of innate immune response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9436	n/a
Ensembl	ENSG00000096264	n/a
UniProt	O95944	n/a
RefSeq (mRNA)	NM_004828 NM_001199509 NM_001199510	n/a
RefSeq (protein)	NP_001186438 NP_001186439 NP_004819	n/a
Location (UCSC)	Chr 6: 41.34 – 41.35 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000096264 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Cantoni C, Bottino C, Vitale M, Pessino A, Augugliaro R, Malaspina A, Parolini S, Moretta L, Moretta A, Biassoni R (Jun 1999). "NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily". J Exp Med. 189 (5): 787–96. doi:10.1084/jem.189.5.787. PMC 2192947. PMID 10049942.
4. "Entrez Gene: NCR2 natural cytotoxicity triggering receptor 2".
5. "NCR2 natural cytotoxicity triggering receptor 2 [Homo sapiens (human)] - Gene - NCBI".

Further reading

• Hershkovitz O, Jivov S, Bloushtain N, et al. (2007). "Characterization of the recognition of tumor cells by the natural cytotoxicity receptor, NKp44". Biochemistry. 46 (25): 7426–36. doi:10.1021/bi7000455. PMID 17536787.
• Forte P, Lilienfeld BG, Baumann BC, Seebach JD (2005). "Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D". J. Immunol. 175 (8): 5463–70. doi:10.4049/jimmunol.175.8.5463. PMID 16210654.
• Fuchs A, Cella M, Kondo T, Colonna M (2005). "Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44". Blood. 106 (6): 2076–82. doi:10.1182/blood-2004-12-4802. PMID 15941912.
• Poggi A, Massaro AM, Negrini S, et al. (2005). "Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors". J. Immunol. 174 (5): 2653–60. doi:10.4049/jimmunol.174.5.2653. PMID 15728472.
• Nowbakht P, Ionescu MC, Rohner A, et al. (2005). "Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias". Blood. 105 (9): 3615–22. doi:10.1182/blood-2004-07-2585. PMID 15657183.
• Campbell KS, Yusa S, Kikuchi-Maki A, Catina TL (2004). "NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence". J. Immunol. 172 (2): 899–906. doi:10.4049/jimmunol.172.2.899. PMID 14707061.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Cantoni C, Ponassi M, Biassoni R, et al. (2004). "The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity". Structure. 11 (6): 725–34. doi:10.1016/S0969-2126(03)00095-9. PMID 12791260.
• Augugliaro R, Parolini S, Castriconi R, et al. (2003). "Selective cross-talk among natural cytotoxicity receptors in human natural killer cells". Eur. J. Immunol. 33 (5): 1235–41. doi:10.1002/eji.200323896. PMID 12731048.
• Allcock RJ, Barrow AD, Forbes S, et al. (2003). "The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44". Eur. J. Immunol. 33 (2): 567–77. doi:10.1002/immu.200310033. PMID 12645956.
• Cantoni C, Ponassi M, Biassoni R, et al. (2003). "Crystallization and preliminary crystallographic characterization of the extracellular Ig-like domain of human natural killer cell activating receptor NKp44". Acta Crystallogr. D. 58 (Pt 10 Pt 2): 1843–5. doi:10.1107/S0907444902012325. PMID 12351833.

External links

• NCR2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Natural cytotoxicity triggering receptor 2 (NCR2)