Dihydropyridine

Dihydropyridine (DHP) is a molecule based upon pyridine, and the parent of a class of molecules that have been semi-saturated with two substituents replacing one double bond. They are particularly well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension. Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure.

Dihydropyridine
Skeletal formula of dihydropyridine
Ball-and-stick model of the dihydropyridine molecule
Names
Systematic IUPAC name
1,4-Dihydropyridine[1]
Identifiers
3D model (JSmol)
ChemSpider
MeSH 1,4-dihydropyridine
UNII
Properties
C
5H
7N
Molar mass 81.1158 g mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Class members

Dihydropyridine class L-type calcium channel blockers include, in alphabetical order (brand names vary in different countries):

NameImageBrand name
Amlodipine
Norvasc, Istin, Normodipine, Tenox, Cordi Cor
Aranidipine
Sapresta (サプレスタ)
Azelnidipine
CalBlock (カルブロック)
Barnidipine
Vasexten, Libradin, Cyress, HypoCa
Benidipine
Coniel
Cilnidipine
Atelec (アテレック), Cilacar, Cinalong, Siscard
Clevidipine
Cleviprex
Cronidipine
Darodipine
Dexniguldipine
Efonidipine
Landel (ランデル)
Elgodipine
Elnadipine
Felodipine
Renedil, Plendil
Flordipine
Furnidipine
Iganidipine
Isradipine
DynaCirc CR
Lacidipine
Lacipil, Motens, Sakure
Lemildipine
Lercanidipine
Zanidip, Zanidip-Recordati
Levamlodipine
EsCordi Cor
Levniguldipine
Manidipine
Manyper, Caslot, Madipine
Nicardipine
Cardene, Cardene SR
Nifedipine
Adalat, Nifedical, Procardia, Corinfar, Cordaflex
Niguldipine
Niludipine
Nilvadipine
Nivadil
Nimodipine
Nimotop
Nisoldipine
Sular, Baymycard, Syscor
Nitrendipine
Baypress, Cardif, Nitrepin, Baylotensin
Olradipine
Oxodipine
Palonidipine
Pranidipine
Acalas
Ryodipine
Sagandipine
Sornidipine
Teludipine
Tiamdipine
Trombodipine
Vatanidipine

The pharmaceutical drug finerenone is also a dihydrophyridine derivative, but does not act as a calcium channel blocker but as an antimineralocorticoid.

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See also

References
  1. "1,4-dihydropyridine - Compound Summary". Pubchem Compound. USA: National Center for Biotechnology Information. 27 March 2005. Identification and Related Records. Retrieved 1 November 2011.
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