Cannabipiperidiethanone

Cannabipiperidiethanone (CPE or 1-(N-methylpiperidin-2-ylmethyl)-3-(2-methoxyphenylacetyl)indole) is a synthetic cannabinoid that has been found as an ingredient of "herbal" synthetic cannabis blends sold in Japan, alongside JWH-122 and JWH-081. Its binding affinity was measured at the CB₁ and CB₂ receptors and it was found to have an IC₅₀ of 591 nM at CB₁ and 968 nM at CB₂, making it 2.3 times and 9.4 times weaker than JWH-250 at these two targets respectively.[1]

Cannabipiperidiethanone

Legal status
Legal status	US: Schedule I
Identifiers
IUPAC name 2-(2-Methoxyphenyl)-1-[1-([1-methylpiperidin-2-yl]methyl)indol-3-yl]ethanone
CAS Number	1345970-43-5
ChemSpider	27330303
UNII	G66388U44D
CompTox Dashboard (EPA)	DTXSID90705471
Chemical and physical data
Formula	C24H28N2O2
Molar mass	376.500 g·mol^−1
3D model (JSmol)	Interactive image
SMILES COc2ccccc2CC(=O)c(c4c1cccc4)cn1CC3CCCCN3C
InChI InChI=1S/C24H28N2O2/c1-25-14-8-7-10-19(25)16-26-17-21(20-11-4-5-12-22(20)26)23(27)15-18-9-3-6-13-24(18)28-2/h3-6,9,11-13,17,19H,7-8,10,14-16H2,1-2H3 Key:AJSBNWAHEDVQJT-UHFFFAOYSA-N

In the United States, CB₁ receptor agonists of the 3-phenylacetylindole class such as cannabipiperidiethanone are Schedule I Controlled Substances.[2]

See also

• AM-1220
• AM-1248
• AM-2233
• JWH-203
• RCS-8

References

1. Uchiyama N, Kikura-Hanajiri R, Goda Y (2011). "Identification of a novel cannabimimetic phenylacetylindole, cannabipiperidiethanone, as a designer drug in a herbal product and its affinity for cannabinoid CB₁ and CB₂ receptors". Chemical & Pharmaceutical Bulletin. 59 (9): 1203–5. doi:10.1248/cpb.59.1203. PMID 21881274.
2. 21 U.S.C. § 812: Schedules of controlled substances