Mucin 5AC

Mucin 5AC (Muc5AC) is a protein that in humans is encoded by the MUC5AC gene.[5][6][7]

MUC5AC
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 5AJN, 5AJP, 5AJO
Identifiers
Aliases	MUC5AC, MUC5, TBM, leB, mucin, mucin 5AC, oligomeric mucus/gel-forming
External IDs	OMIM: 158373 MGI: 104697 HomoloGene: 137237 GeneCards: MUC5AC
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 1,157,953 bp[1] End 1,201,138 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F5|7 87.23 cM Start 141,788,972 bp[2] End 141,819,231 bp[2]
Gene ontology Molecular function • extracellular matrix structural constituent Cellular component • cytoplasm • Golgi lumen • extracellular region • extracellular exosome • extracellular • cell membrane • mucus layer Biological process • phosphatidylinositol-mediated signaling • O-glycan processing • stimulatory C-type lectin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4586	17833
Ensembl	ENSG00000215182 ENSG00000283158	ENSMUSG00000037974
UniProt	P98088	n/a
RefSeq (mRNA)	NM_017511 NM_001304359	NM_010844
RefSeq (protein)	NP_001291288	n/a
Location (UCSC)	Chr 11: 1.16 – 1.2 Mb	Chr 7: 141.79 – 141.82 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Clinical relevance

This gene has been linked to mucus hypersecretion in the respiratory tract and is associated to chronic obstructive pulmonary disease (COPD).[8]

References

1. ENSG00000283158 GRCh38: Ensembl release 89: ENSG00000215182, ENSG00000283158 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037974 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N (Feb 1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". Biochem J. 305 (Pt 1): 211–9. PMC 1136451. PMID 7826332.
6. van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW (Jun 1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif". Biochem Biophys Res Commun. 245 (3): 853–9. doi:10.1006/bbrc.1998.8535. PMID 9588204.
7. "Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming".
8. Wang G, Xu Z, Wang R, Al-Hijji M, Salit J, Strulovici-Barel Y, Tilley A, Mezey J, Crystal R (June 2012). "Genes associated with MUC5AC expression in small airway epithelium of human smokers and nonsmokers". BMC Med. Genom. 5 (1): 21. doi:10.1186/1755-8794-5-21. PMC 3443416. PMID 22676183.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Mucin-5AC