NE-CHMIMO

NE-CHMIMO (CHM-018) is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB₁ receptor and has been sold online as a designer drug.[1][2][3] NE-CHMIMO is the 1-cyclohexylmethyl (instead of 1-pentyl) analogue of the first-generation synthetic cannabinoid JWH-018. The corresponding cyclohexylmethyl derivative of JWH-081 had also been reported several months earlier.[4]

NE-CHMIMO

Legal status
Legal status	CA: Schedule II DE: Anlage II (Authorized trade only, not prescriptible) UK: Under Psychoactive Substances Act US: Schedule I Illegal in Japan
Identifiers
IUPAC name [1-(Cyclohexylmethyl)-1H-indol-3-yl](naphthalen-1-yl)methanone
CAS Number	1373876-11-9
PubChem CID	139031057
Chemical and physical data
Formula	C26H25NO
Molar mass	367.492 g·mol^−1
3D model (JSmol)	Interactive image
SMILES O=C(c1cccc2ccccc12)c3cn(CC4CCCCC4)c5ccccc35
InChI InChI=1S/C26H25NO/c28-26(23-15-8-12-20-11-4-5-13-21(20)23)24-18-27(17-19-9-2-1-3-10-19)25-16-7-6-14-22(24)25/h4-8,11-16,18-19H,1-3,9-10,17H2 Key:HGJYPIZWMHHQKS-UHFFFAOYSA-N

Legal status

In the United States, all CB₁ receptor agonists of the 3-(1-naphthoyl)indole class such as NE-CHMIMO are Schedule I Controlled Substances.[5]

NE-CHMIMO is a controlled substance in Japan as of November 2019.[6]

See also

• AB-CHMINACA
• ADB-CHMINACA
• APP-CHMINACA
• FUB-018
• MDMB-CHMICA
• MDMB-CHMINACA

References

1. Angerer, Verena; Bisel, Philippe; Moosmann, Bjoern; Westphal, Folker; Auwärter, Volker (September 2016). "Separation and structural characterization of the new synthetic cannabinoid JWH-018 cyclohexyl methyl derivative "NE-CHMIMO" using flash chromatography, GC-MS, IR and NMR spectroscopy". Forensic Science International. 266: e93–e98. doi:10.1016/j.forsciint.2016.05.031. ISSN 0379-0738. PMID 27297324.
2. Franz, Florian; Jechle, Hanna; Angerer, Verena; Pegoro, Melanie; Auwärter, Volker; Neukamm, Merja A. (May 2018). "Synthetic cannabinoids in hair – Pragmatic approach for method updates, compound prevalences and concentration ranges in authentic hair samples". Analytica Chimica Acta. 1006: 61–73. doi:10.1016/j.aca.2017.12.029. ISSN 0003-2670. PMID 30016265.
3. "NE-CHMIMO". New Synthetic Drugs Database.
4. Blakey, Karen; Boyd, Sue; Atkinson, Sarah; Wolf, Jenna; Slottje, Pim M.; Goodchild, Katrina; McGowan, Jenny (March 2016). "Identification of the novel synthetic cannabimimetic 8-quinolinyl 4-methyl-3-(1-piperidinylsulfonyl)benzoate (QMPSB) and other designer drugs in herbal incense". Forensic Science International. 260: 40–53. doi:10.1016/j.forsciint.2015.12.001. ISSN 0379-0738. PMID 26795397.
5. 21 U.S.C. § 812: Schedules of controlled substances
6. "指定薬物を指定する省令が公布されました｜厚生労働省". www.mhlw.go.jp (in Japanese). Ministry of Health, Labour and Welfare. Retrieved 2019-12-22.