CEACAM5

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a member of the carcinoembryonic antigen (CEA) gene family.[3]

CEACAM5
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1E07, 2QSQ, 2QST, 2VER
Identifiers
Aliases	CEACAM5, CD66e, CEA, carcinoembryonic antigen related cell adhesion molecule 5, CEA cell adhesion molecule 5
External IDs	OMIM: 114890 HomoloGene: 128801 GeneCards: CEACAM5
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 41,708,585 bp[1] End 41,730,433 bp[1]
Gene ontology Molecular function • GPI anchor binding • protein homodimerization activity • identical protein binding Cellular component • anchored component of membrane • basolateral plasma membrane • integral component of plasma membrane • extracellular exosome • membrane • integral component of external side of plasma membrane • extracellular region • cell membrane • cell surface • apical plasma membrane Biological process • homotypic cell-cell adhesion • negative regulation of apoptotic process • negative regulation of anoikis • negative regulation of myotube differentiation • C-terminal protein lipidation • leukocyte migration • apoptotic process • cell adhesion • homophilic cell adhesion via plasma membrane adhesion molecules • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1048	n/a
Ensembl	ENSG00000105388	n/a
UniProt	P06731	n/a
RefSeq (mRNA)	NM_001291484 NM_001308398 NM_004363	n/a
RefSeq (protein)	NP_001278413 NP_001295327 NP_004354	n/a
Location (UCSC)	Chr 19: 41.71 – 41.73 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

See also

• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000105388 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5".

Further reading

• Willcocks TC, Craig IW (1991). "Characterization of the genomic organization of human carcinoembryonic antigen (CEA): comparison with other family members and sequence analysis of 5' controlling region". Genomics. 8 (3): 492–500. doi:10.1016/0888-7543(90)90036-T. PMID 2286372.
• Barnett T, Zimmermann W (1990). "Workshop report: proposed nomenclature for the carcinoembryonic antigen (CEA) gene family". Tumour Biol. 11 (1–2): 59–63. doi:10.1159/000217643. PMID 2309067.
• Schrewe H, Thompson J, Bona M, et al. (1990). "Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression". Mol. Cell. Biol. 10 (6): 2738–48. doi:10.1128/MCB.10.6.2738. PMC 360634. PMID 2342461.
• Kamarck ME, Elting JJ, Hart JT, et al. (1987). "Carcinoembryonic antigen family: expression in a mouse L-cell transfectant and characterization of a partial cDNA in bacteriophage lambda gt11". Proc. Natl. Acad. Sci. U.S.A. 84 (15): 5350–4. Bibcode:1987PNAS...84.5350K. doi:10.1073/pnas.84.15.5350. PMC 298853. PMID 2955415.
• Zimmermann W, Ortlieb B, Friedrich R, von Kleist S (1987). "Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure". Proc. Natl. Acad. Sci. U.S.A. 84 (9): 2960–4. Bibcode:1987PNAS...84.2960Z. doi:10.1073/pnas.84.9.2960. PMC 304780. PMID 3033671.
• Barnett T, Goebel SJ, Nothdurft MA, Elting JJ (1989). "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains". Genomics. 3 (1): 59–66. doi:10.1016/0888-7543(88)90160-7. PMID 3220478.
• Zimmermann W, Weber B, Ortlieb B, et al. (1988). "Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors". Cancer Res. 48 (9): 2550–4. PMID 3356015.
• Beauchemin N, Benchimol S, Cournoyer D, et al. (1987). "Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen". Mol. Cell. Biol. 7 (9): 3221–30. doi:10.1128/MCB.7.9.3221. PMC 367958. PMID 3670312.
• Oikawa S, Nakazato H, Kosaki G (1987). "Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence". Biochem. Biophys. Res. Commun. 142 (2): 511–8. doi:10.1016/0006-291X(87)90304-4. PMID 3814146.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hart SP, Ross JA, Ross K, et al. (2000). "Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes". Cell Death Differ. 7 (5): 493–503. doi:10.1038/sj.cdd.4400680. PMID 10800083.
• Guignot J, Peiffer I, Bernet-Camard MF, et al. (2000). "Recruitment of CD55 and CD66e Brush Border-Associated Glycosylphosphatidylinositol-Anchored Proteins by Members of the Afa/Dr Diffusely Adhering Family of Escherichia coli That Infect the Human Polarized Intestinal Caco-2/TC7 Cells". Infect. Immun. 68 (6): 3554–63. doi:10.1128/IAI.68.6.3554-3563.2000. PMC 97642. PMID 10816511.
• Boehm MK, Perkins SJ (2000). "Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23". FEBS Lett. 475 (1): 11–6. doi:10.1016/S0014-5793(00)01612-4. PMID 10854848.
• Screaton RA, DeMarte L, Dráber P, Stanners CP (2000). "The Specificity for the Differentiation Blocking Activity of Carcinoembryonic Antigen Resides in Its Glycophosphatidyl-Inositol Anchor". J. Cell Biol. 150 (3): 613–26. doi:10.1083/jcb.150.3.613. PMC 2175204. PMID 10931872.
• Bajenova OV, Zimmer R, Stolper E, et al. (2001). "Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells". J. Biol. Chem. 276 (33): 31067–73. doi:10.1074/jbc.M104093200. PMID 11406629.
• Wirth T, Soeth E, Czubayko F, Juhl H (2002). "Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth". Clin. Exp. Metastasis. 19 (2): 155–60. doi:10.1023/A:1014566127493. PMID 11964079.
• Louhimo J, Carpelan-Holmström M, Alfthan H, et al. (2002). "Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer". Int. J. Cancer. 101 (6): 545–8. doi:10.1002/ijc.90009. PMID 12237895.
• Hampton R, Walker M, Marshall J, Juhl H (2002). "Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells". Oncogene. 21 (51): 7817–23. doi:10.1038/sj.onc.1205906. PMID 12420218.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

External links

• CEACAM5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CEACAM5 genome location and CEACAM5 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.