CEACAM8

Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8) also known as CD66b (Cluster of Differentiation 66b), is a member of the carcinoembryonic antigen (CEA) gene family. Its main function is cell adhesion, cell migration, and pathogen binding.[3]

CEACAM8
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2DKS, 4Y88, 4YIQ, 4WTZ
Identifiers
Aliases	CEACAM8, CD66b, CD67, CGM6, NCA-95, carcinoembryonic antigen related cell adhesion molecule 8, CEA cell adhesion molecule 8
External IDs	OMIM: 615747 HomoloGene: 68205 GeneCards: CEACAM8
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 42,580,243 bp[1] End 42,595,055 bp[1]
Gene ontology Molecular function • GO:0001948 protein binding • protein heterodimerization activity Cellular component • anchored component of membrane • cell membrane • integral component of plasma membrane • extracellular exosome • membrane • extracellular • azurophil granule membrane • specific granule membrane • tertiary granule membrane • cell surface Biological process • immune response • leukocyte migration • neutrophil degranulation • cell adhesion • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1088	n/a
Ensembl	ENSG00000124469	n/a
UniProt	P31997	n/a
RefSeq (mRNA)	NM_001816	n/a
RefSeq (protein)	NP_001807	n/a
Location (UCSC)	Chr 19: 42.58 – 42.6 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Use

CEACAM8 is expressed exclusively on granulocytes and used as granulocyte marker.

See also

• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000124469 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8".

Further reading

• Khan WN, Frängsmyr L, Teglund S, et al. (1992). "Identification of three new genes and estimation of the size of the carcinoembryonic antigen family". Genomics. 14 (2): 384–90. doi:10.1016/S0888-7543(05)80230-7. PMID 1427854.
• Oikawa S, Inuzuka C, Kuroki M, et al. (1991). "A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains". J. Biol. Chem. 266 (13): 7995–8001. PMID 2022629.
• Berling B, Kolbinger F, Grunert F, et al. (1990). "Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow". Cancer Res. 50 (20): 6534–9. PMID 2208113.
• Arakawa F, Kuroki M, Misumi Y, et al. (1990). "Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family". Biochem. Biophys. Res. Commun. 166 (3): 1063–71. doi:10.1016/0006-291X(90)90975-S. PMID 2306228.
• Eades-Perner AM, Thompson J, van der Putten H, Zimmermann W (1998). "Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes". Blood. 91 (2): 663–72. doi:10.1182/blood.V91.2.663. PMID 9427723.
• Torsteinsdóttir I, Arvidson NG, Hällgren R, Håkansson L (1999). "Enhanced expression of integrins and CD66b on peripheral blood neutrophils and eosinophils in patients with rheumatoid arthritis, and the effect of glucocorticoids". Scand. J. Immunol. 50 (4): 433–9. doi:10.1046/j.1365-3083.1999.00602.x. PMID 10520185.
• Oikawa S, Sugiyama M, Kuroki M, et al. (2001). "Extracellular N-domain alone can mediate specific heterophilic adhesion between members of the carcinoembryonic antigen family, CEACAM6 and CEACAM8". Biochem. Biophys. Res. Commun. 278 (3): 564–8. doi:10.1006/bbrc.2000.3858. PMID 11095950.
• Singer BB, Scheffrahn I, Heymann R, et al. (2002). "Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes". J. Immunol. 168 (10): 5139–46. doi:10.4049/jimmunol.168.10.5139. PMID 11994468.
• Zhao L, Xu S, Peterson C, et al. (2002). "Purification and characterization of a 95-kDa protein--carcinoembryonic antigen-related cell adhesion molecule 8--from normal human granulocytes". J. Immunol. Methods. 270 (1): 27–35. doi:10.1016/s0022-1759(02)00215-6. PMID 12379336.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ramachandran P, Boontheung P, Xie Y, et al. (2006). "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry". J. Proteome Res. 5 (6): 1493–503. doi:10.1021/pr050492k. PMID 16740002.

External links

• CEACAM8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CEACAM8 genome location and CEACAM8 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.