Acyl-CoA hydrolase
In enzymology, an acyl-CoA hydrolase (EC 3.1.2.20) is an enzyme that catalyzes the chemical reaction
- acyl-CoA + H2O CoA + a carboxylate
| acyl-CoA hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.2.20 | ||||||||
| CAS number | 37270-64-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are acyl-CoA and H2O, whereas its two products are CoA and carboxylate.
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is acyl-CoA hydrolase. Other names in common use include acyl coenzyme A thioesterase, acyl-CoA thioesterase, acyl coenzyme A hydrolase, thioesterase B, thioesterase II, and acyl-CoA thioesterase.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1Y7U and 2GVH.
gollark: I mean, it's not very extensible and XTMF has more player options available.
gollark: I wasn't aware of this "libMusicFS", so it's not the same, no.
gollark: https://pastebin.com/SPyr8jrh has a rough specification.
gollark: The eXtensible Tape Metadata Format.
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References
- Alexson SE, Svensson LT, Nedergaard J (1989). "NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of the rat". Biochim. Biophys. Acta. 1005 (1): 13–9. doi:10.1016/0005-2760(89)90025-8. PMID 2570608.
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