Ubiquitin carboxyl-terminal hydrolase L5

Ubiquitin carboxyl-terminal hydrolase isozyme L5 is an enzyme that in humans is encoded by the UCHL5 gene.[5][6][7]

UCHL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3A7S, 3IHR, 3RII, 3RIS, 3TB3, 4UEL, 4UEM, 4UF5, 4UF6, 4WLP
Identifiers
Aliases	UCHL5, CGI-70, INO80R, UCH-L5, UCH37, Ubiquitin carboxyl-terminal hydrolase L5, ubiquitin C-terminal hydrolase L5
External IDs	OMIM: 610667 MGI: 1914848 HomoloGene: 9326 GeneCards: UCHL5
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q31.2 Start 193,012,250 bp[1] End 193,060,080 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 F|1 62.54 cM Start 143,777,272 bp[2] End 143,807,466 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cysteine-type peptidase activity • thiol-dependent ubiquitinyl hydrolase activity • peptidase activity • GO:0001948 protein binding • thiol-dependent ubiquitin-specific protease activity • endopeptidase inhibitor activity • hydrolase activity • RNA binding • proteasome binding Cellular component • cytoplasm • intracellular • proteasome complex • cell nucleus • cytosolic proteasome complex • nucleoplasm • mitochondrion • cytosol • Ino80 complex Biological process • regulation of proteasomal protein catabolic process • DNA recombination • regulation of transcription, DNA-templated • lateral ventricle development • ubiquitin-dependent protein catabolic process • transcription, DNA-templated • proteolysis • cellular response to DNA damage stimulus • forebrain morphogenesis • DNA repair • midbrain development • negative regulation of endopeptidase activity • protein deubiquitination • negative regulation of proteasomal ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51377	56207
Ensembl	ENSG00000116750	ENSMUSG00000018189
UniProt	Q9Y5K5 Q5LJB0	Q9WUP7
RefSeq (mRNA)	NM_001199261 NM_001199262 NM_001199263 NM_015984 NM_001350840 NM_001350841 NM_001350842 NM_001350843 NM_001350844 NM_001350845 NM_001350846 NM_001350847 NM_001350848 NM_001350849 NM_001350850 NM_001350851 NM_001350852	NM_001159866 NM_019562
RefSeq (protein)	NP_001186190 NP_001186191 NP_001186192 NP_057068 NP_001337769 NP_001337770 NP_001337771 NP_001337772 NP_001337773 NP_001337774 NP_001337775 NP_001337776 NP_001337777 NP_001337778 NP_001337779 NP_001337780 NP_001337781	NP_001153338 NP_062508
Location (UCSC)	Chr 1: 193.01 – 193.06 Mb	Chr 1: 143.78 – 143.81 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000116750 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018189 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
6. Wicks SJ, Haros K, Maillard M, Song L, Cohen RE, Dijke PT, Chantry A (Dec 2005). "The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling". Oncogene. 24 (54): 8080–4. doi:10.1038/sj.onc.1208944. PMID 16027725.
7. "Entrez Gene: UCHL5 ubiquitin carboxyl-terminal hydrolase L5".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Li T, Duan W, Yang H, et al. (2001). "Identification of two proteins, S14 and UIP1, that interact with UCH37". FEBS Lett. 488 (3): 201–5. doi:10.1016/S0014-5793(00)02436-4. hdl:10536/DRO/DU:30009147. PMID 11163772.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Rolén U, Kobzeva V, Gasparjan N, et al. (2006). "Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines". Mol. Carcinog. 45 (4): 260–9. doi:10.1002/mc.20177. PMID 16402389.
• Gandhi TK, Zhong J, Mathivanan S, et al. (2006). "Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets". Nat. Genet. 38 (3): 285–93. doi:10.1038/ng1747. PMID 16501559.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Yao T, Song L, Xu W, et al. (2006). "Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1". Nat. Cell Biol. 8 (9): 994–1002. doi:10.1038/ncb1460. PMID 16906146.
• Hamazaki J, Iemura S, Natsume T, et al. (2006). "A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes". EMBO J. 25 (19): 4524–36. doi:10.1038/sj.emboj.7601338. PMC 1589993. PMID 16990800.
• Qiu XB, Ouyang SY, Li CJ, et al. (2007). "hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37". EMBO J. 25 (24): 5742–53. doi:10.1038/sj.emboj.7601450. PMC 1698896. PMID 17139257.