UCHL3

Ubiquitin carboxyl-terminal hydrolase isozyme L3 is an enzyme that in humans is encoded by the UCHL3 gene.[5][6]

UCHL3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUCHL3, UCH-L3, ubiquitin C-terminal hydrolase L3
External IDsOMIM: 603090 MGI: 1355274 HomoloGene: 4377 GeneCards: UCHL3
Gene location (Human)
Chr.Chromosome 13 (human)[1]
Band13q22.2Start75,549,480 bp[1]
End75,606,020 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7347

50933

Ensembl

ENSG00000118939

ENSMUSG00000022111

UniProt

P15374

Q9JKB1

RefSeq (mRNA)

NM_001270952
NM_006002

NM_016723

RefSeq (protein)

NP_001257881
NP_005993

NP_057932

Location (UCSC)Chr 13: 75.55 – 75.61 MbChr 14: 101.65 – 101.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

UCHL3 has been shown to interact with NEDD8 and the tauopathy and synucleinopathy associated mutated ubiquitin molecule UBB+1.[7][8]

gollark: I mean in general, not this particular case.
gollark: Do you think the electoral college does not do this?
gollark: > Because in Michigan, those particular cities usually decide the votes due to their high population. I'm going to call it "favouring rural people" if they get more voting power than they would if it was proportional to actual population.
gollark: You could also call that a "representative democracy", but I don't think disputing definitions is helpful.
gollark: Are you saying that the electoral college system does *not* favour rural people over city ones, in general?

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000118939 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022111 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wilkinson KD, Lee KM, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J (Dec 1989). "The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase". Science. 246 (4930): 670–3. doi:10.1126/science.2530630. PMID 2530630.
  6. "Entrez Gene: UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)".
  7. Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW (July 2011). "Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)". FEBS Lett. 585 (16): 2568–74. doi:10.1016/j.febslet.2011.06.037. PMID 21762696.
  8. Wada H, Kito K, Caskey LS, Yeh ET, Kamitani T (October 1998). "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochem. Biophys. Res. Commun. 251 (3): 688–92. doi:10.1006/bbrc.1998.9532. PMID 9790970.

Further reading


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