UCHL3

Ubiquitin carboxyl-terminal hydrolase isozyme L3 is an enzyme that in humans is encoded by the UCHL3 gene.[5][6]

UCHL3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUCHL3, UCH-L3, ubiquitin C-terminal hydrolase L3
External IDsOMIM: 603090 MGI: 1355274 HomoloGene: 4377 GeneCards: UCHL3
Gene location (Human)
Chr.Chromosome 13 (human)[1]
Band13q22.2Start75,549,480 bp[1]
End75,606,020 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7347

50933

Ensembl

ENSG00000118939

ENSMUSG00000022111

UniProt

P15374

Q9JKB1

RefSeq (mRNA)

NM_001270952
NM_006002

NM_016723

RefSeq (protein)

NP_001257881
NP_005993

NP_057932

Location (UCSC)Chr 13: 75.55 – 75.61 MbChr 14: 101.65 – 101.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

UCHL3 has been shown to interact with NEDD8 and the tauopathy and synucleinopathy associated mutated ubiquitin molecule UBB+1.[7][8]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000118939 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022111 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wilkinson KD, Lee KM, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J (Dec 1989). "The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase". Science. 246 (4930): 670–3. doi:10.1126/science.2530630. PMID 2530630.
  6. "Entrez Gene: UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)".
  7. Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW (July 2011). "Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)". FEBS Lett. 585 (16): 2568–74. doi:10.1016/j.febslet.2011.06.037. PMID 21762696.
  8. Wada H, Kito K, Caskey LS, Yeh ET, Kamitani T (October 1998). "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochem. Biophys. Res. Commun. 251 (3): 688–92. doi:10.1006/bbrc.1998.9532. PMID 9790970.

Further reading


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