CD244

CD244 (Cluster of Differentiation 244) is a human protein encoded by the CD244 gene.[5] It is also known as Natural Killer Cell Receptor 2B4[6]

Not to be confused with KIR2DL4.

CD244
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z2K, 2PTT, 2PTU
Identifiers
Aliases	CD244, 2B4, NAIL, NKR2B4, Nmrk, SLAMF4, CD244 molecule
External IDs	OMIM: 605554 MGI: 109294 HomoloGene: 9493 GeneCards: CD244
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 160,830,160 bp[1] End 160,862,887 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.52 cM Start 171,559,193 bp[2] End 171,609,746 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • MHC class I protein binding • GO:0001948 protein binding • signaling receptor activity Cellular component • cell membrane • membrane • integral component of membrane • external side of plasma membrane Biological process • innate immune system • positive regulation of granzyme B production • positive regulation of interleukin-8 secretion • immune system process • leukocyte migration • adaptive immune response • positive regulation of interferon-gamma secretion • signal transduction • positive regulation of inositol phosphate biosynthetic process • immune response • natural killer cell activation involved in immune response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51744	18106
Ensembl	ENSG00000122223	ENSMUSG00000004709
UniProt	Q9BZW8	Q07763
RefSeq (mRNA)	NM_001166663 NM_001166664 NM_016382	NM_018729
RefSeq (protein)	NP_001160135 NP_001160136 NP_057466	NP_061199
Location (UCSC)	Chr 1: 160.83 – 160.86 Mb	Chr 1: 171.56 – 171.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a cell surface receptor expressed on natural killer cells (NK cells) (and some T cells) mediating non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[7] CD244 can also be expressed on non-lymphocytes such as eosinophils, mast cells and dendritic cells.[8]

See also

• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000122223 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004709 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CD244 CD244 molecule, natural killer cell receptor 2B4".
6. Online Mendelian Inheritance in Man (OMIM): 605554
7. "CD244 molecule, natural killer cell receptor 2B4 ( Homo sapiens (human) )".
8. Georgoudaki AM, Khodabandeh S, Puiac S, Persson CM, Larsson MK, Lind M, Hammarfjord O, Nabatti TH, Wallin RP, Yrlid U, Rhen M, Kumar V, Chambers BJ (2015). "CD244 is expressed on dendritic cells and regulates their functions". Immunol Cell Biol. 93 (6): 581–90. doi:10.1038/icb.2014.124. PMID 25643613.

Further reading

• Vaidya SV, Mathew PA (2006). "Of mice and men: different functions of the murine and human 2B4 (CD244) receptor on NK cells". Immunol. Lett. 105 (2): 180–4. doi:10.1016/j.imlet.2006.02.006. PMID 16621032.
• Siu G, Strauss EC, Lai E, Hood LE (1986). "Analysis of a human V beta gene subfamily". J. Exp. Med. 164 (5): 1600–14. doi:10.1084/jem.164.5.1600. PMC 2188445. PMID 3772297.
• Latchman Y, McKay PF, Reiser H (1998). "Identification of the 2B4 molecule as a counter-receptor for CD48". J. Immunol. 161 (11): 5809–12. PMID 9834056.
• Brown MH, Boles K, van der Merwe PA, et al. (1999). "2B4, the Natural Killer and T Cell Immunoglobulin Superfamily Surface Protein, Is a Ligand for CD48". J. Exp. Med. 188 (11): 2083–90. doi:10.1084/jem.188.11.2083. PMC 2212392. PMID 9841922.
• Tangye SG, Lazetic S, Woollatt E, et al. (1999). "Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP". J. Immunol. 162 (12): 6981–5. PMID 10358138.
• Nakajima H, Cella M, Langen H, et al. (1999). "Activating interactions in human NK cell recognition: the role of 2B4-CD48". Eur. J. Immunol. 29 (5): 1676–83. doi:10.1002/(SICI)1521-4141(199905)29:05<1676::AID-IMMU1676>3.0.CO;2-Y. PMID 10359122.
• Boles KS, Nakajima H, Colonna M, et al. (1999). "Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4". Tissue Antigens. 54 (1): 27–34. doi:10.1034/j.1399-0039.1999.540103.x. PMID 10458320.
• Kubin MZ, Parshley DL, Din W, et al. (1999). "Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48". Eur. J. Immunol. 29 (11): 3466–77. doi:10.1002/(SICI)1521-4141(199911)29:11<3466::AID-IMMU3466>3.0.CO;2-9. PMID 10556801.
• Parolini S, Bottino C, Falco M, et al. (2000). "X-Linked Lymphoproliferative Disease: 2b4 Molecules Displaying Inhibitory Rather than Activating Function Are Responsible for the Inability of Natural Killer Cells to Kill Epstein-Barr Virus–Infected Cells". J. Exp. Med. 192 (3): 337–46. doi:10.1084/jem.192.3.337. PMC 2193227. PMID 10934222.
• Kumaresan PR, Mathew PA (2000). "Structure of the human natural killer cell receptor 2B4 gene and identification of a novel alternative transcript". Immunogenetics. 51 (11): 987–92. doi:10.1007/s002510000237. PMID 11003394.
• Watzl C, Stebbins CC, Long EO (2000). "NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244)". J. Immunol. 165 (7): 3545–8. doi:10.4049/jimmunol.165.7.3545. PMID 11034353.
• Tangye SG, Cherwinski H, Lanier LL, Phillips JH (2001). "2B4-mediated activation of human natural killer cells". Mol. Immunol. 37 (9): 493–501. doi:10.1016/S0161-5890(00)00076-6. PMID 11163399.
• Chuang SS, Pham HT, Kumaresan PR, Mathew PA (2001). "A prominent role for activator protein-1 in the transcription of the human 2B4 (CD244) gene in NK cells". J. Immunol. 166 (10): 6188–95. doi:10.4049/jimmunol.166.10.6188. PMID 11342640.
• Morra M, Simarro-Grande M, Martin M, et al. (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients" (PDF). J. Biol. Chem. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068.
• Morra M, Lu J, Poy F, et al. (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425.
• Speiser DE, Colonna M, Ayyoub M, et al. (2002). "The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells". J. Immunol. 167 (11): 6165–70. doi:10.4049/jimmunol.167.11.6165. PMID 11714776.
• Chuang SS, Kumaresan PR, Mathew PA (2002). "2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways". J. Immunol. 167 (11): 6210–6. doi:10.4049/jimmunol.167.11.6210. PMID 11714782.
• Bottino C, Parolini S, Biassoni R, et al. (2002). X-linked lymphoproliferative disease: the dark side of 2b4 function. Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 495. pp. 63–7. doi:10.1007/978-1-4615-0685-0_9. ISBN 978-1-4613-5194-8. PMID 11774610.
• Aoukaty A, Tan R (2002). "Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase". J. Biol. Chem. 277 (15): 13331–7. doi:10.1074/jbc.M112029200. PMID 11815622.
• Sivori S, Falco M, Marcenaro E, et al. (2002). "Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4526–31. doi:10.1073/pnas.072065999. PMC 123681. PMID 11917118.
• Assarsson E, Kambayshi T, Persson C, et al. (2005). "2B4 co-stimulation: NK cells and their control of adaptive immune responses". Mol. Immunol. 42 (4): 419–23. doi:10.1016/j.molimm.2004.07.021. PMID 15607793.

External links

• CD244+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CD244 genome location and CD244 gene details page in the UCSC Genome Browser.