CD244

CD244 (Cluster of Differentiation 244) is a human protein encoded by the CD244 gene.[5] It is also known as Natural Killer Cell Receptor 2B4[6]

CD244
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD244, 2B4, NAIL, NKR2B4, Nmrk, SLAMF4, CD244 molecule
External IDsOMIM: 605554 MGI: 109294 HomoloGene: 9493 GeneCards: CD244
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q23.3Start160,830,160 bp[1]
End160,862,887 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51744

18106

Ensembl

ENSG00000122223

ENSMUSG00000004709

UniProt

Q9BZW8

Q07763

RefSeq (mRNA)

NM_001166663
NM_001166664
NM_016382

NM_018729

RefSeq (protein)

NP_001160135
NP_001160136
NP_057466

NP_061199

Location (UCSC)Chr 1: 160.83 – 160.86 MbChr 1: 171.56 – 171.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a cell surface receptor expressed on natural killer cells (NK cells) (and some T cells) mediating non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[7] CD244 can also be expressed on non-lymphocytes such as eosinophils, mast cells and dendritic cells.[8]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000122223 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000004709 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CD244 CD244 molecule, natural killer cell receptor 2B4".
  6. Online Mendelian Inheritance in Man (OMIM): 605554
  7. "CD244 molecule, natural killer cell receptor 2B4 ( Homo sapiens (human) )".
  8. Georgoudaki AM, Khodabandeh S, Puiac S, Persson CM, Larsson MK, Lind M, Hammarfjord O, Nabatti TH, Wallin RP, Yrlid U, Rhen M, Kumar V, Chambers BJ (2015). "CD244 is expressed on dendritic cells and regulates their functions". Immunol Cell Biol. 93 (6): 581–90. doi:10.1038/icb.2014.124. PMID 25643613.

Further reading


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