TENC1

Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.[5]

TNS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DKQ, 2KNO, 2L6K, 2LOZ, 3HQC
Identifiers
Aliases	TNS2, C1-TEN, C1TEN, TENC1, tensin 2
External IDs	OMIM: 607717 MGI: 2387586 HomoloGene: 37077 GeneCards: TNS2
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 53,046,969 bp[1] End 53,064,372 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F2|15 57.29 cM Start 102,100,413 bp[2] End 102,116,401 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • kinase binding • phosphoprotein phosphatase activity • GO:0001948 protein binding • hydrolase activity • metal ion binding Cellular component • cell junction • cell membrane • intracellular • membrane • focal adhesion Biological process • protein dephosphorylation • collagen metabolic process • GO:0007243 intracellular signal transduction • multicellular organismal homeostasis • response to muscle activity • cellular homeostasis • kidney development • negative regulation of cell proliferation • multicellular organism growth Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23371	209039
Ensembl	ENSG00000111077	ENSMUSG00000037003
UniProt	Q63HR2	Q8CGB6
RefSeq (mRNA)	NM_015319 NM_170754 NM_198316	NM_153533 NM_001355636
RefSeq (protein)	NP_056134 NP_736610 NP_938072	NP_705761 NP_001342565
Location (UCSC)	Chr 12: 53.05 – 53.06 Mb	Chr 15: 102.1 – 102.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[5]

Interactions

TENC1 has been shown to interact with AXL receptor tyrosine kinase.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000111077 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037003 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TENC1 tensin like C1 domain containing phosphatase (tensin 2)".
6. Hafizi, Sassan; Alindri Filiz; Karlsson Roger; Dahlbäck Björn (Dec 2002). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. United States. 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. ISSN 0006-291X. PMID 12470648.

Further reading

• Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Chen H, Duncan IC, Bozorgchami H, Lo SH (2002). "Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 733–8. Bibcode:2002PNAS...99..733C. doi:10.1073/pnas.022518699. PMC 117374. PMID 11792844.
• Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. PMID 12470648.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Calderwood DA, Fujioka Y, de Pereda JM, et al. (2003). "Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2272–7. Bibcode:2003PNAS..100.2272C. doi:10.1073/pnas.262791999. PMC 151330. PMID 12606711.
• Hu Y, Fang X, Dunham SM, et al. (2004). "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling". J. Biol. Chem. 279 (28): 29325–35. doi:10.1074/jbc.M311144200. PMID 15117958.
• Hafizi S, Ibraimi F, Dahlbäck B (2006). "C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration". FASEB J. 19 (8): 971–3. doi:10.1096/fj.04-2532fje. PMID 15817639.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Yam JW, Ko FC, Chan CY, et al. (2006). "Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma". Hepatology. 44 (4): 881–90. doi:10.1002/hep.21339. PMID 17006924.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Tensin-2