DUSP15

Dual specificity protein phosphatase 15 is an enzyme that in humans is encoded by the DUSP15 gene.[5][6]

DUSP15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YZ4
Identifiers
Aliases	DUSP15, VHY, C20orf57, dual specificity phosphatase 15
External IDs	OMIM: 616776 MGI: 1934928 HomoloGene: 33586 GeneCards: DUSP15
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.21 Start 31,847,637 bp[1] End 31,870,747 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 152,940,997 bp[2] End 152,951,698 bp[2]
Gene ontology Molecular function • phosphoprotein phosphatase activity • hydrolase activity • GO:0001948 protein binding • phosphatase activity • protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity Cellular component • membrane • cytoplasm • cytosol • cell membrane Biological process • positive regulation of JNK cascade • transforming growth factor beta receptor signaling pathway • protein dephosphorylation • regulation of cell proliferation • peptidyl-tyrosine dephosphorylation • dephosphorylation • regulation of oligodendrocyte differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	128853	252864
Ensembl	ENSG00000149599	ENSMUSG00000042662
UniProt	Q9H1R2	Q8R4V2
RefSeq (mRNA)	NM_177991 NM_001012644 NM_080611 NM_001320478 NM_001320479	NM_001159376 NM_145744
RefSeq (protein)	NP_001012662 NP_001307407 NP_001307408 NP_542178 NP_817130	NP_001152848 NP_665687
Location (UCSC)	Chr 20: 31.85 – 31.87 Mb	Chr 2: 152.94 – 152.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the non-receptor class of the protein-tyrosine phosphatase family. The encoded protein has both protein-tyrosine phosphatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. Three transcript variants, encoding two different isoforms have been found for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000149599 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042662 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Alonso A, Narisawa S, Bogetz J, Tautz L, Hadzic R, Huynh H, Williams S, Gjorloff Wingren A, Bremer MC, Holsinger LJ, Millan JL, Mustelin T (Jul 2004). "VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX". J Biol Chem. 279 (31): 32586–91. doi:10.1074/jbc.M403442200. PMID 15138252.
6. "Entrez Gene: DUSP15 dual specificity phosphatase 15".

Further reading

• Yoon TS, Jeong DG, Kim JH, et al. (2006). "Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase". Proteins. 61 (3): 694–7. doi:10.1002/prot.20642. PMID 16170801.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Dual specificity protein phosphatase 15