PTPN3

Tyrosine-protein phosphatase non-receptor type 3 is an enzyme that in humans is encoded by the PTPN3 gene.[5][6]

PTPN3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B49, 4QUM, 4QUN, 4RH5, 4RH9, 4RHG, 4RI4, 4RI5, 4S0G
Identifiers
Aliases	PTPN3, PTP-H1, PTPH1, protein tyrosine phosphatase, non-receptor type 3, protein tyrosine phosphatase non-receptor type 3
External IDs	OMIM: 176877 MGI: 105307 HomoloGene: 74451 GeneCards: PTPN3
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q31.3 Start 109,375,466 bp[1] End 109,498,313 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 B3|4 31.66 cM Start 57,190,841 bp[2] End 57,301,837 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • sodium channel regulator activity • phosphoprotein phosphatase activity • phosphatase activity • phosphotyrosine residue binding • ATPase binding • cytoskeletal protein binding • GO:0001948 protein binding • protein tyrosine phosphatase activity • hydrolase activity Cellular component • cytoplasm • membrane • cytoplasmic side of plasma membrane • cytoskeleton • cell membrane Biological process • regulation of membrane depolarization during action potential • protein dephosphorylation • liver regeneration • regulation of sodium ion transmembrane transporter activity • negative regulation of membrane protein ectodomain proteolysis • negative regulation of mitotic cell cycle • dephosphorylation • peptidyl-tyrosine dephosphorylation • negative regulation of epidermal growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5774	545622
Ensembl	ENSG00000070159	ENSMUSG00000038764
UniProt	P26045	A2ALK8
RefSeq (mRNA)	NM_001145368 NM_001145369 NM_001145370 NM_001145371 NM_001145372 NM_002829	NM_011207 NM_001384115
RefSeq (protein)	NP_001138840 NP_001138841 NP_001138842 NP_001138843 NP_001138844 NP_002820	NP_035337 NP_001371044
Location (UCSC)	Chr 9: 109.38 – 109.5 Mb	Chr 4: 57.19 – 57.3 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta.[6]

Interactions

PTPN3 has been shown to interact with YWHAB.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000070159 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038764 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yang Q, Tonks NK (August 1991). "Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin". Proc Natl Acad Sci USA. 88 (14): 5949–53. doi:10.1073/pnas.88.14.5949. PMC 51999. PMID 1648725.
6. "Entrez Gene: PTPN3 protein tyrosine phosphatase, non-receptor type 3".
7. Zhang SH, Kobayashi R, Graves PR, Piwnica-Worms H, Tonks NK (October 1997). "Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein". J. Biol. Chem. 272 (43): 27281–7. doi:10.1074/jbc.272.43.27281. PMID 9341175.

Further reading

• Arimura Y, Hinoda Y, Itoh F, Takekawa M, Tsujisaki M, Adachi M, Imai K, Yachi A (1992). "cDNA cloning of new protein tyrosine phosphatases in the human colon". Tumour Biol. 13 (3): 180–6. doi:10.1159/000217763. PMID 1626183.
• Ikuta S, Itoh F, Hinoda Y, Toyota M, Makiguchi Y, Imai K, Yachi A (1995). "Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma". J. Gastroenterol. 29 (6): 727–32. doi:10.1007/BF02349278. PMID 7874267.
• Itoh F, Ikuta S, Hinoda Y, Arimura Y, Ohe M, Adachi M, Ariyama T, Inazawa J, Imai K, Yachi A (1994). "Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal-associated proteins". Int. J. Cancer. 55 (6): 947–51. doi:10.1002/ijc.2910550612. PMID 8253532.
• Zhang SH, Kobayashi R, Graves PR, Piwnica-Worms H, Tonks NK (1997). "Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein". J. Biol. Chem. 272 (43): 27281–7. doi:10.1074/jbc.272.43.27281. PMID 9341175.
• Zhang SH, Liu J, Kobayashi R, Tonks NK (1999). "Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1". J. Biol. Chem. 274 (25): 17806–12. doi:10.1074/jbc.274.25.17806. PMID 10364224.
• Gjörloff-Wingren A, Saxena M, Han S, Wang X, Alonso A, Renedo M, Oh P, Williams S, Schnitzer J, Mustelin T (2000). "Subcellular localization of intracellular protein tyrosine phosphatases in T cells". Eur. J. Immunol. 30 (8): 2412–21. doi:10.1002/1521-4141(2000)30:8<2412::AID-IMMU2412>3.0.CO;2-J. PMID 10940933.
• Zheng Y, Schlondorff J, Blobel CP (2003). "Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1". J. Biol. Chem. 277 (45): 42463–70. doi:10.1074/jbc.M207459200. PMID 12207026.
• Sozio MS, Mathis MA, Young JA, Wälchli S, Pitcher LA, Wrage PC, Bartók B, Campbell A, Watts JD, Aebersold R, Hooft van Huijsduijnen R, van Oers NS (2004). "PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit". J. Biol. Chem. 279 (9): 7760–9. doi:10.1074/jbc.M309994200. PMID 14672952.
• Blanchetot C, Chagnon M, Dubé N, Hallé M, Tremblay ML (2005). "Substrate-trapping techniques in the identification of cellular PTP targets". Methods. 35 (1): 44–53. doi:10.1016/j.ymeth.2004.07.007. PMID 15588985.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Jespersen T, Gavillet B, van Bemmelen MX, Cordonier S, Thomas MA, Staub O, Abriel H (2006). "Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1". Biochem. Biophys. Res. Commun. 348 (4): 1455–62. doi:10.1016/j.bbrc.2006.08.014. PMID 16930557.
• Jing M, Bohl J, Brimer N, Kinter M, Vande Pol SB (2007). "Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins". J. Virol. 81 (5): 2231–9. doi:10.1128/JVI.01979-06. PMC 1865939. PMID 17166906.
• Töpffer S, Müller-Schiffmann A, Matentzoglu K, Scheffner M, Steger G (2007). "Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses". J. Gen. Virol. 88 (Pt 11): 2956–65. doi:10.1099/vir.0.83123-0. PMID 17947517.