PTPRO

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.[5][6][7]

PTPRO
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2G59, 2GJT
Identifiers
Aliases	PTPRO, GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O, protein tyrosine phosphatase, receptor type O, protein tyrosine phosphatase receptor type O
External IDs	OMIM: 600579 MGI: 1097152 HomoloGene: 21564 GeneCards: PTPRO
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p12.3|12p13-p12 Start 15,322,508 bp[1] End 15,598,331 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G1 Start 137,252,319 bp[2] End 137,463,233 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • phosphoprotein phosphatase activity • protein homodimerization activity • phosphatase activity • Wnt-protein binding • GO:0001948 protein binding • protein tyrosine phosphatase activity • transmembrane receptor protein tyrosine phosphatase activity • hydrolase activity Cellular component • integral component of membrane • lateral plasma membrane • membrane • growth cone • cell membrane • dendritic spine • integral component of plasma membrane • axon • apical plasma membrane • neuron projection • extracellular exosome • lamellipodium • glutamatergic synapse • GABA-ergic synapse • integral component of postsynaptic density membrane Biological process • negative regulation of cell-substrate adhesion • negative regulation of neuron projection development • monocyte chemotaxis • negative regulation of retinal ganglion cell axon guidance • regulation of glomerular filtration • slit diaphragm assembly • protein dephosphorylation • glomerulus development • axon guidance • cell morphogenesis • glomerular visceral epithelial cell differentiation • peptidyl-tyrosine dephosphorylation • negative regulation of glomerular filtration • negative regulation of canonical Wnt signaling pathway • lamellipodium assembly • dephosphorylation • regulation of synapse organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5800	19277
Ensembl	ENSG00000151490	ENSMUSG00000030223
UniProt	Q16827	E9Q612
RefSeq (mRNA)	NM_002848 NM_030667 NM_030668 NM_030669 NM_030670 NM_030671	NM_001164401 NM_001164402 NM_001164403 NM_011216
RefSeq (protein)	NP_002839 NP_109592 NP_109593 NP_109594 NP_109595 NP_109596	NP_001157873 NP_001157874 NP_001157875 NP_035346
Location (UCSC)	Chr 12: 15.32 – 15.6 Mb	Chr 6: 137.25 – 137.46 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000151490 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030223 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Thomas PE, Wharram BL, Goyal M, Wiggins JE, Holzman LB, Wiggins RC (Sep 1994). "GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit". J Biol Chem. 269 (31): 19953–62. PMID 7519601.
6. Wiggins RC, Wiggins JE, Goyal M, Wharram BL, Thomas PE (Oct 1995). "Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13". Genomics. 27 (1): 174–81. doi:10.1006/geno.1995.1021. PMID 7665166.
7. "Entrez Gene: PTPRO protein tyrosine phosphatase, receptor type, O".

Further reading

• Seimiya H, Sawabe T, Inazawa J, Tsuruo T (1995). "Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents". Oncogene. 10 (9): 1731–8. PMID 7753550.
• Feito MJ, Bragardo M, Buonfiglio D, et al. (1997). "gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules". Int. Immunol. 9 (8): 1141–7. doi:10.1093/intimm/9.8.1141. PMID 9263011.
• Avraham S, London R, Tulloch GA, et al. (1998). "Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells". Gene. 204 (1–2): 5–16. doi:10.1016/S0378-1119(97)00420-4. PMID 9434160.
• Taniguchi Y, London R, Schinkmann K, et al. (1999). "The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor". Blood. 94 (2): 539–49. PMID 10397721.
• Aguiar RC, Yakushijin Y, Kharbanda S, et al. (1999). "PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest". Blood. 94 (7): 2403–13. PMID 10498613.
• Wang Z, Bhattacharya N, Meyer MK, et al. (2001). "Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells". Arch. Biochem. Biophys. 390 (1): 9–18. doi:10.1006/abbi.2001.2370. PMID 11368509.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Motiwala T, Kutay H, Ghoshal K, et al. (2004). "Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer". Proc. Natl. Acad. Sci. U.S.A. 101 (38): 13844–9. doi:10.1073/pnas.0405451101. PMC 518843. PMID 15356345.
• Chen L, Juszczynski P, Takeyama K, et al. (2007). "Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation". Blood. 108 (10): 3428–33. doi:10.1182/blood-2006-03-013821. PMID 16888096.
• Motiwala T, Majumder S, Kutay H, et al. (2007). "Methylation and Silencing of Protein Tyrosine Phosphatase Receptor Type O in Chronic Lymphocytic Leukemia". Clin. Cancer Res. 13 (11): 3174–81. doi:10.1158/1078-0432.CCR-06-1720. PMC 3074612. PMID 17545520.
• Tian J, Wang HP, Mao YY, et al. (2007). "Reduced glomerular epithelial protein 1 expression and podocyte injury in immunoglobulin A nephropathy". J. Int. Med. Res. 35 (3): 338–45. doi:10.1177/147323000703500308. PMID 17593862.