DUSP16

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.[5][6][7][8]

DUSP16
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2VSW, 3TG3, 4YR8
Identifiers
Aliases	DUSP16, MKP-7, MKP7, dual specificity phosphatase 16
External IDs	OMIM: 607175 MGI: 1917936 HomoloGene: 15604 GeneCards: DUSP16
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.2 Start 12,473,282 bp[1] End 12,562,863 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G1|6 65.77 cM Start 134,715,468 bp[2] End 134,792,625 bp[2]
Gene ontology Molecular function • protein tyrosine phosphatase activity • MAP kinase tyrosine/serine/threonine phosphatase activity • phosphoprotein phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity • phosphatase activity Cellular component • cytoplasm • cytosol • cytoplasmic vesicle • cell nucleus • nucleoplasm Biological process • inactivation of MAPK activity • MAPK export from nucleus • protein dephosphorylation • peptidyl-tyrosine dephosphorylation • MAPK phosphatase export from nucleus, leptomycin B sensitive • negative regulation of MAPK cascade • dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80824	70686
Ensembl	ENSG00000280962 ENSG00000111266	ENSMUSG00000030203
UniProt	Q9BY84	n/a
RefSeq (mRNA)	NM_030640	NM_001048054 NM_130447 NM_181320
RefSeq (protein)	NP_085143 NP_085143.1	n/a
Location (UCSC)	Chr 12: 12.47 – 12.56 Mb	Chr 6: 134.72 – 134.79 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.[supplied by OMIM][8]

Interactions

DUSP16 has been shown to interact with MAPK14[9][10] and MAPK8IP1.[11]

References

1. ENSG00000111266 GRCh38: Ensembl release 89: ENSG00000280962, ENSG00000111266 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030203 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tanoue T, Yamamoto T, Maeda R, Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J Biol Chem. 276 (28): 26629–39. doi:10.1074/jbc.M101981200. PMID 11359773.
6. Masuda K, Shima H, Watanabe M, Kikuchi K (Oct 2001). "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein". J Biol Chem. 276 (42): 39002–11. doi:10.1074/jbc.M104600200. PMID 11489891.
7. Willoughby EA, Collins MK (Jul 2005). "Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2". J Biol Chem. 280 (27): 25651–8. doi:10.1074/jbc.M501926200. PMID 15888437.
8. "Entrez Gene: DUSP16 dual specificity phosphatase 16".
9. Tanoue, T; Yamamoto T; Maeda R; Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J. Biol. Chem. United States. 276 (28): 26629–39. doi:10.1074/jbc.M101981200. ISSN 0021-9258. PMID 11359773.
10. Masuda, K; Shima H; Watanabe M; Kikuchi K (Oct 2001). "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein". J. Biol. Chem. United States. 276 (42): 39002–11. doi:10.1074/jbc.M104600200. ISSN 0021-9258. PMID 11489891.
11. Willoughby, Emma A; Perkins Gordon R; Collins Mary K; Whitmarsh Alan J (Mar 2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK". J. Biol. Chem. United States. 278 (12): 10731–6. doi:10.1074/jbc.M207324200. ISSN 0021-9258. PMID 12524447.

Further reading

• Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Willoughby EA, Perkins GR, Collins MK, Whitmarsh AJ (2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK". J. Biol. Chem. 278 (12): 10731–6. doi:10.1074/jbc.M207324200. PMID 12524447.
• Masuda K, Shima H, Katagiri C, Kikuchi K (2003). "Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446". J. Biol. Chem. 278 (34): 32448–56. doi:10.1074/jbc.M213254200. PMID 12794087.
• Hoornaert I, Marynen P, Goris J, et al. (2003). "MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation". Oncogene. 22 (49): 7728–36. doi:10.1038/sj.onc.1207089. PMID 14586399.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Katagiri C, Masuda K, Urano T, et al. (2005). "Phosphorylation of Ser-446 determines stability of MKP-7". J. Biol. Chem. 280 (15): 14716–22. doi:10.1074/jbc.M500200200. PMID 15689616.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Dual specificity protein phosphatase 16