DUSP18

Dual specificity protein phosphatase 18 is an enzyme that is encoded by the DUSP18 gene in humans.[5][6]

DUSP18
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ESB
Identifiers
Aliases	DUSP18, DSP18, DUSP20, LMWDSP20, bK963H5.1, dual specificity phosphatase 18
External IDs	OMIM: 611446 MGI: 1922469 HomoloGene: 34984 GeneCards: DUSP18
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 30,652,051 bp[1] End 30,667,890 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 3,895,240 bp[2] End 3,901,296 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein tyrosine phosphatase activity • MAP kinase tyrosine/serine/threonine phosphatase activity • phosphoprotein phosphatase activity • hydrolase activity • phosphatase activity • protein tyrosine/serine/threonine phosphatase activity Cellular component • cytoplasm • cell nucleus • nucleoplasm • mitochondrion • membrane • mitochondrial inner membrane Biological process • inactivation of MAPK activity • protein dephosphorylation • peptidyl-tyrosine dephosphorylation • peptidyl-threonine dephosphorylation • dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	150290	75219
Ensembl	ENSG00000167065	ENSMUSG00000047205
UniProt	Q8NEJ0	Q8VE01
RefSeq (mRNA)	NM_001304794 NM_001304795 NM_001304796 NM_152511	NM_173745
RefSeq (protein)	NP_001291723 NP_001291724 NP_001291725 NP_689724	NP_776106
Location (UCSC)	Chr 22: 30.65 – 30.67 Mb	Chr 11: 3.9 – 3.9 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000167065 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047205 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hood KL, Tobin JF, Yoon C (Oct 2002). "Identification and characterization of two novel low-molecular-weight dual specificity phosphatases". Biochem Biophys Res Commun. 298 (4): 545–51. doi:10.1016/S0006-291X(02)02488-9. PMID 12408986.
6. "Entrez Gene: DUSP18 dual specificity phosphatase 18".

Further reading

• Wu Q, Huang S, Sun Y, et al. (2006). "Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo". Front. Biosci. 11: 2714–24. doi:10.2741/2001. PMID 16720344.
• Jeong DG, Cho YH, Yoon TS, et al. (2006). "Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family". Acta Crystallogr. D. 62 (Pt 6): 582–8. doi:10.1107/S0907444906010109. PMID 16699184.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Wu Q, Gu S, Dai J, et al. (2003). "Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain". Biochim. Biophys. Acta. 1625 (3): 296–304. doi:10.1016/s0167-4781(02)00629-2. PMID 12591617.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Dual specificity protein phosphatase 18 (DUSP18)