PTPRR

Protein tyrosine phosphatase receptor-type R is an enzyme that in humans is encoded by the PTPRR gene.[5][6][7]

PTPRR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPRR, EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ, protein tyrosine phosphatase, receptor type R, protein tyrosine phosphatase receptor type R
External IDsOMIM: 602853 MGI: 109559 HomoloGene: 2135 GeneCards: PTPRR
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q15Start70,638,073 bp[1]
End70,920,738 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5801

19279

Ensembl

ENSG00000153233

ENSMUSG00000020151

UniProt

Q15256

Q62132

RefSeq (mRNA)

NM_001207015
NM_001207016
NM_002849
NM_130846

RefSeq (protein)

NP_001193944
NP_001193945
NP_002840
NP_570897

Location (UCSC)Chr 12: 70.64 – 70.92 MbChr 10: 116.02 – 116.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP. The similar gene predominately expressed in mouse brain was found to associate with, and thus regulate the activity and cellular localization of MAP kinases. The rat counterpart of this gene was reported to be regulated by the nerve growth factor, which suggested the function of this gene in neuronal growth and differentiation.[7]

Interactions

PTPRR has been shown to interact with MAPK7.[8]

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References

  1. GRCh38: Ensembl release 89: ENSG00000153233 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020151 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shiozuka K, Watanabe Y, Ikeda T, Hashimoto S, Kawashima H (Nov 1995). "Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase". Gene. 162 (2): 279–84. doi:10.1016/0378-1119(95)00306-Q. PMID 7557444.
  6. van den Maagdenberg AM, Schepens JT, Schepens MT, Merkx GF, Darroudi F, Wieringa B, Geurts van Kessel A, Hendriks WJ (Jul 1999). "Assignment1 of the PTP-SL/PTPBR7 gene (Ptprr/PTPRR) to mouse chromosome region 8A2 by in situ hybridization". Cytogenet Cell Genet. 84 (3–4): 243–4. doi:10.1159/000015268. PMID 10393441.
  7. "Entrez Gene: PTPRR protein tyrosine phosphatase, receptor type, R".
  8. Buschbeck M, Eickhoff J, Sommer MN, Ullrich A (Aug 2002). "Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway". J. Biol. Chem. 277 (33): 29503–9. doi:10.1074/jbc.M202149200. PMID 12042304.

Further reading


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