RNGTT

mRNA-capping enzyme is a protein that in humans is encoded by the RNGTT gene.[5][6][7]

RNGTT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C46, 3S24
Identifiers
Aliases	RNGTT, CAP1A, HCE, HCE1, hCAP, RNA guanylyltransferase and 5'-phosphatase
External IDs	OMIM: 603512 MGI: 1329041 HomoloGene: 37851 GeneCards: RNGTT
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q15 Start 88,609,897 bp[1] End 88,963,618 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 33,310,311 bp[2] End 33,502,614 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein tyrosine/serine/threonine phosphatase activity • phosphatase activity • protein tyrosine phosphatase activity • polynucleotide 5'-phosphatase activity • RNA guanylyltransferase activity • triphosphatase activity • nucleotidyltransferase activity • mRNA guanylyltransferase activity • catalytic activity • hydrolase activity • nucleotide binding • GTP binding • transferase activity • GO:0001948 protein binding Cellular component • cell nucleus • nucleoplasm Biological process • mRNA processing • RNA processing • protein dephosphorylation • transcription from RNA polymerase II promoter • dephosphorylation • 7-methylguanosine mRNA capping • metabolism • peptidyl-tyrosine dephosphorylation • polynucleotide 5' dephosphorylation • GO:0022415 viral process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8732	24018
Ensembl	ENSG00000111880	ENSMUSG00000028274
UniProt	O60942	O55236
RefSeq (mRNA)	NM_001286426 NM_001286428 NM_003800	NM_011884 NM_001305273
RefSeq (protein)	NP_001273355 NP_001273357 NP_003791	NP_001292202 NP_036014
Location (UCSC)	Chr 6: 88.61 – 88.96 Mb	Chr 4: 33.31 – 33.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000111880 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028274 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ (Jan 1999). "Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively". Genomics. 54 (2): 351–3. doi:10.1006/geno.1998.5604. PMID 9828141.
6. Yamada-Okabe T, Doi R, Shimmi O, Arisawa M, Yamada-Okabe H (May 1998). "Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme". Nucleic Acids Res. 26 (7): 1700–6. doi:10.1093/nar/26.7.1700. PMC 147440. PMID 9512541.
7. "Entrez Gene: RNGTT RNA guanylyltransferase and 5'-phosphatase".

Further reading

• Yue Z, Maldonado E, Pillutla R, et al. (1998). "Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12898–903. doi:10.1073/pnas.94.24.12898. PMC 24235. PMID 9371772.
• Tsukamoto T, Shibagaki Y, Murakoshi T, et al. (1998). "Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme". Biochem. Biophys. Res. Commun. 243 (1): 101–8. doi:10.1006/bbrc.1997.8038. PMID 9473487.
• Pillutla RC, Yue Z, Maldonado E, Shatkin AJ (1998). "Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes". J. Biol. Chem. 273 (34): 21443–6. doi:10.1074/jbc.273.34.21443. PMID 9705270.
• Wen Y, Shatkin AJ (1999). "Transcription elongation factor hSPT5 stimulates mRNA capping". Genes Dev. 13 (14): 1774–9. doi:10.1101/gad.13.14.1774. PMC 316881. PMID 10421630.
• Chiu YL, Coronel E, Ho CK, et al. (2001). "HIV-1 Tat protein interacts with mammalian capping enzyme and stimulates capping of TAR RNA". J. Biol. Chem. 276 (16): 12959–66. doi:10.1074/jbc.M007901200. PMID 11278368.
• Chiu YL, Ho CK, Saha N, et al. (2002). "Tat stimulates cotranscriptional capping of HIV mRNA". Mol. Cell. 10 (3): 585–97. doi:10.1016/S1097-2765(02)00630-5. PMID 12408826.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhou M, Deng L, Kashanchi F, et al. (2004). "The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA". Proc. Natl. Acad. Sci. U.S.A. 100 (22): 12666–71. doi:10.1073/pnas.1835726100. PMC 240675. PMID 14569024.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human mRNA-capping enzyme (RNGTT)