Protein-secreting ATPase

In enzymology, a protein-secreting ATPase (EC 3.6.3.50) is an enzyme that catalyzes the chemical reaction

ATP + H2O ADP + phosphate
protein-exporting ATPase
Identifiers
EC number3.6.3.50
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are ATP and H2O, whereas its two products are ADP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (protein-secreting).

See also

References

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    • Thomas JD, Reeves PJ, Salmond GP (1997). "The general secretion pathway of Erwinia carotovora subsp carotovora: analysis of the membrane topology of OutC and OutF". Microbiology. 143 (3): 713–20. doi:10.1099/00221287-143-3-713. PMID 9084158.
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    • Martinez A, Ostrovsky P, Nunn DN (1998). "Identification of an additional member of the secretin superfamily of proteins in Pseudomonas aeruginosa that is able to function in type II protein secretion". Mol. Microbiol. 28 (6): 1235–46. doi:10.1046/j.1365-2958.1998.00888.x. PMID 9680212.
    • Schuch R, Maurelli AT (1999). "The Mxi-Spa Type III Secretory Pathway of Shigella flexneri Requires an Outer Membrane Lipoprotein, MxiM, for Invasin Translocation". Infect. Immun. 67 (4): 1982–91. PMC 96556. PMID 10085046.


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