Proamanullin

Proamanullin
Names
	Other names 2-L-Proline-3-isoleucine-alpha-amanitin
Identifiers
CAS Number	54532-46-6 ;
3D model (JSmol)	Interactive image;
ChemSpider	48308194 ;
PubChem CID	171350;
	InChI InChI=1S/C39H54N10O11S/c1-5-18(3)31-36(57)42-15-29(52)43-26-17-61(60)38-22(21-10-9-20(50)12-23(21)46-38)13-24(33(54)41-16-30(53)47-31)44-37(58)32(19(4)6-2)48-35(56)27-8-7-11-49(27)39(59)25(14-28(40)51)45-34(26)55/h9-10,12,18-19,24-27,31-32,46,50H,5-8,11,13-17H2,1-4H3,(H2,40,51)(H,41,54)(H,42,57)(H,43,52)(H,44,58)(H,45,55)(H,47,53)(H,48,56)/t18-,19-,24-,25-,26-,27-,31-,32-,61?/m0/s1 Key: CTYHFRWAIRSHQT-YRDOMICZSA-N ; InChI=1/C39H54N10O11S/c1-5-18(3)31-36(57)42-15-29(52)43-26-17-61(60)38-22(21-10-9-20(50)12-23(21)46-38)13-24(33(54)41-16-30(53)47-31)44-37(58)32(19(4)6-2)48-35(56)27-8-7-11-49(27)39(59)25(14-28(40)51)45-34(26)55/h9-10,12,18-19,24-27,31-32,46,50H,5-8,11,13-17H2,1-4H3,(H2,40,51)(H,41,54)(H,42,57)(H,43,52)(H,44,58)(H,45,55)(H,47,53)(H,48,56)/t18-,19-,24-,25-,26-,27-,31-,32-,61?/m0/s1 Key: CTYHFRWAIRSHQT-YRDOMICZBU;
	SMILES O=C(NCC(N[C@@](C(NCC(N[C@@H](C3)C(N[C@@H](CC(N)=O)C(N5[C@H]4CCC5)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)[C@H](CC1=C(S3=O)NC2=C1C=CC(O)=C2)NC([C@@]([C@@H](C)CC)([H])N[C@@]4=O)=O;
Properties
Chemical formula	C39H54N10O11S
Molar mass	870.97 g/mol
Appearance	Colorless, odorless
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

Promanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in the mushroom genus Amanita.

Toxicology

Like other amatoxins, proamanullin is an inhibitor of RNA polymerase II. Promanullin has a specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).[1]

gollark: Apparently my CPU is at 49 degC, the WiFi adapter is at 33 degC, the chipset is at 50.5 degC, and the "ACPI interface" says 55.

gollark: Intel® 64 architecture delivers 64-bit computing on server, workstation, desktop and mobile platforms when combined with supporting software.¹ Intel 64 architecture improves performance by allowing systems to address more than 4 GB of both virtual and physical memory, however.

gollark: They might be. If you flip all the belts and splitters.

gollark: Oh, I got the direction wrong. Still valid.

gollark: Well, balancers are symmetric maybe.

References

Cochet-Meilhac M, Chambon P (June 1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim. Biophys. Acta. 353 (2): 160–84. doi:10.1016/0005-2787(74)90182-8. PMID 4601749.

External links

Amatoxins REVISED

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[1] Cochet-Meilhac M, Chambon P (June 1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim. Biophys. Acta. 353 (2): 160–84. doi:10.1016/0005-2787(74)90182-8. PMID 4601749.

Proamanullin

Toxicology

See also

References

External links