Amanullinic acid

Amanullinic acid
Names
	Other names 1-L-Aspartic acid-3-isoleucine-alpha-amanitin
Identifiers
CAS Number	54532-45-5 ;
3D model (JSmol)	Interactive image;
ChemSpider	149798 ;
PubChem CID	171349;
	InChI InChI=1S/C39H53N9O13S/c1-5-17(3)31-36(58)41-13-28(51)42-26-16-62(61)38-22(21-8-7-19(49)9-23(21)45-38)11-24(33(55)40-14-29(52)46-31)43-37(59)32(18(4)6-2)47-35(57)27-10-20(50)15-48(27)39(60)25(12-30(53)54)44-34(26)56/h7-9,17-18,20,24-27,31-32,45,49-50H,5-6,10-16H2,1-4H3,(H,40,55)(H,41,58)(H,42,51)(H,43,59)(H,44,56)(H,46,52)(H,47,57)(H,53,54) Key: HFENEIQMWRYNGK-UHFFFAOYSA-N ; InChI=1/C39H53N9O13S/c1-5-17(3)31-36(58)41-13-28(51)42-26-16-62(61)38-22(21-8-7-19(49)9-23(21)45-38)11-24(33(55)40-14-29(52)46-31)43-37(59)32(18(4)6-2)47-35(57)27-10-20(50)15-48(27)39(60)25(12-30(53)54)44-34(26)56/h7-9,17-18,20,24-27,31-32,45,49-50H,5-6,10-16H2,1-4H3,(H,40,55)(H,41,58)(H,42,51)(H,43,59)(H,44,56)(H,46,52)(H,47,57)(H,53,54) Key: HFENEIQMWRYNGK-UHFFFAOYAM;
	SMILES O=C(NCC(N[C@@](C(NCC(N[C@@H](C3)C(N[C@@H](CC(O)=O)C(N5[C@H]4C[C@@H](O)C5)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)[C@H](CC1=C(S3=O)NC2=C1C=CC(O)=C2)NC([C@@]([C@@H](C)CC)([H])N[C@@]4=O)=O;
Properties
Chemical formula	C39H53N9O13S
Molar mass	887.96 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

Amanullinic acid is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the mushroom genus Amanita. Amanullinic acid is relatively non-toxic( oral LD₅₀ >20 mg/kg in mice).[1]

Toxicology

Like other amatoxins, amanullinic acid is an inhibitor of RNA polymerase II.

gollark: In general something like```lualocal h = http.get "whatever URL"local text = h.readAll()h.close()```to download a file to the variable `text`.

gollark: Yes.

gollark: We should ban coroutines. Only with strong government regulation can we prevent their misuse.

gollark: It's probably hard to give much help since this will mostly be down to whatever insanity the compiler does.

gollark: C#? This is Lua; are you offloading stuff to a remote server somehow?

References

T. Wieland; Faulstich H. (1978). "Amatoxins, Phallotoxins, Phallolysin, and Antamanide: the Biologically Active Components of Poisonous Amanita Mushrooms". CRC Critical Reviews in Biochemistry. 5 (3): 185–260. doi:10.3109/10409237809149870. PMID 363352.

External links

Amatoxins REVISED

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] T. Wieland; Faulstich H. (1978). "Amatoxins, Phallotoxins, Phallolysin, and Antamanide: the Biologically Active Components of Poisonous Amanita Mushrooms". CRC Critical Reviews in Biochemistry. 5 (3): 185–260. doi:10.3109/10409237809149870. PMID 363352.

Amanullinic acid

Toxicology

See also

References

External links