CYP20A1

CYP20A1 (cytochrome P450, family 20, subfamily A, polypeptide 1) is a protein which in humans is encoded by the CYP20A1 gene.[5]

CYP20A1
Identifiers
Aliases	CYP20A1, CYP-M, cytochrome P450 family 20 subfamily A member 1
External IDs	MGI: 1925201 HomoloGene: 18584 GeneCards: CYP20A1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.2 Start 203,238,940 bp[1] End 203,305,611 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C2 Start 60,343,323 bp[2] End 60,388,060 bp[2]
Gene ontology Molecular function • monooxygenase activity • iron ion binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • heme binding • metal ion binding • oxidoreductase activity Cellular component • integral component of membrane • membrane Biological process • oxidation-reduction process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57404	77951
Ensembl	ENSG00000119004	ENSMUSG00000049439
UniProt	Q6UW02	Q8BKE6
RefSeq (mRNA)	NM_020674 NM_177538	NM_030013 NM_001313721
RefSeq (protein)	NP_803882 NP_001358624 NP_001358625 NP_001358626 NP_001358627 NP_001358628 NP_001358629 NP_001358630 NP_001358631 NP_001358632 NP_001358633 NP_001358634 NP_001358635	NP_001300650 NP_084289
Location (UCSC)	Chr 2: 203.24 – 203.31 Mb	Chr 1: 60.34 – 60.39 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000119004 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049439 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
6. "Entrez Gene: CY20A1".

External links

• Human CYP20A1 genome location and CYP20A1 gene details page in the UCSC Genome Browser.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jiang JH, Jia WH, Qin HD, et al. (2004). "[Expression of cytochrome P450 enzymes in human nasopharyngeal carcinoma and non-cancerous nasopharynx tissue]". AI Zheng. 23 (6): 672–7. PMID 15191668.
• Werck-Reichhart D, Feyereisen R (2000). "Cytochromes P450: a success story". Genome Biol. 1 (6): REVIEWS3003. doi:10.1186/gb-2000-1-6-reviews3003. PMC 138896. PMID 11178272.
• Ross CJ, Katzov-Eckert H, Dubé MP, et al. (2009). "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy". Nat. Genet. 41 (12): 1345–9. doi:10.1038/ng.478. PMID 19898482.
• Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
• Smith G, Stubbins MJ, Harries LW, Wolf CR (1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica. 28 (12): 1129–65. doi:10.1080/004982598238868. PMID 9890157.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.