Cholest-4-en-3-one 26-monooxygenase

Cholest-4-en-3-one 26-monooxygenase (EC 1.14.13.141, CYP125, CYP125A1, cholest-4-en-3-one 27-monooxygenase) is an enzyme with systematic name cholest-4-en-3-one,NADH:oxygen oxidoreductase (26-hydroxylating).[1][2][3][4] This enzyme catalyses the following chemical reaction

cholest-4-en-3-one + NADH + H+ + O2 26-hydroxycholest-4-en-3-one + NAD+ + H2O
Cholest-4-en-3-one 26-monooxygenase
Identifiers
EC number1.14.13.141
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Cholest-4-en-3-one 26-monooxygenase is a heme thiolate (P450) enzyme.

References
  1. Rosłoniec KZ, Wilbrink MH, Capyk JK, Mohn WW, Ostendorf M, van der Geize R, Dijkhuizen L, Eltis LD (December 2009). "Cytochrome P450 125 (CYP125) catalyses C26-hydroxylation to initiate sterol side-chain degradation in Rhodococcus jostii RHA1". Molecular Microbiology. 74 (5): 1031–43. doi:10.1111/j.1365-2958.2009.06915.x. PMC 5218833. PMID 19843222.
  2. McLean KJ, Lafite P, Levy C, Cheesman MR, Mast N, Pikuleva IA, Leys D, Munro AW (December 2009). "The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection". The Journal of Biological Chemistry. 284 (51): 35524–33. doi:10.1074/jbc.M109.032706. PMC 2790982. PMID 19846552.
  3. Capyk JK, Kalscheuer R, Stewart GR, Liu J, Kwon H, Zhao R, Okamoto S, Jacobs WR, Eltis LD, Mohn WW (December 2009). "Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids". The Journal of Biological Chemistry. 284 (51): 35534–42. doi:10.1074/jbc.M109.072132. PMC 2790983. PMID 19846551.
  4. Ouellet H, Guan S, Johnston JB, Chow ED, Kells PM, Burlingame AL, Cox JS, Podust LM, de Montellano PR (August 2010). "Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one". Molecular Microbiology. 77 (3): 730–42. doi:10.1111/j.1365-2958.2010.07243.x. PMC 2909382. PMID 20545858.
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