CYP4X1

CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1) is a protein which in humans is encoded by the CYP4X1 gene.[5]

CYP4X1
Identifiers
Aliases	CYP4X1, CYPIVX1, cytochrome P450 family 4 subfamily X member 1
External IDs	OMIM: 614999 MGI: 1932403 HomoloGene: 75853 GeneCards: CYP4X1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p33|1 Start 47,023,669 bp[1] End 47,050,751 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D1 Start 115,106,323 bp[2] End 115,134,281 bp[2]
Gene ontology Molecular function • iron ion binding • oxidoreductase activity • aromatase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • metal ion binding • monooxygenase activity Cellular component • integral component of membrane • organelle membrane • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • intracellular membrane-bounded organelle Biological process • oxidation-reduction process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	260293	81906
Ensembl	ENSG00000186377	ENSMUSG00000047155
UniProt	Q8N118	Q6A152
RefSeq (mRNA)	NM_178033 NM_001320289 NM_001320290	NM_001003947
RefSeq (protein)	NP_001307218 NP_001307219 NP_828847	NP_001003947
Location (UCSC)	Chr 1: 47.02 – 47.05 Mb	Chr 4: 115.11 – 115.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000186377 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047155 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bylund J, Zhang C, Harder DR (August 2002). "Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain". Biochem. Biophys. Res. Commun. 296 (3): 677–84. doi:10.1016/S0006-291X(02)00918-X. PMID 12176035.
6. "Entrez Gene: CYP4X1".

Further reading

• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Savas U, Hsu MH, Griffin KJ, et al. (2005). "Conditional regulation of the human CYP4X1 and CYP4Z1 genes". Arch. Biochem. Biophys. 436 (2): 377–85. doi:10.1016/j.abb.2005.02.022. PMID 15797250.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.