Geraniol 8-hydroxylase
Geraniol 8-hydroxylase (EC 1.14.14.83, CYP76B6, G10H, CrG10H, SmG10H) is an enzyme with systematic name geraniol,NADPH:oxygen oxidoreductase (8-hydroxylating).[1][2][3] This enzyme catalyses the following chemical reaction
- geraniol + NADPH + H+ + O2 (6E)-8-hydroxygeraniol + NADP+ + H2O
| Geraniol 8-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.14.83 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Geraniol 8-hydroxylase is a cytochrome P450 and therefore requires a partner cytochrome P450 reductase for functional expression.
References
- Collu G, Unver N, Peltenburg-Looman AM, van der Heijden R, Verpoorte R, Memelink J (November 2001). "Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis". FEBS Letters. 508 (2): 215–20. doi:10.1016/s0014-5793(01)03045-9. PMID 11718718.
- Wang J, Liu Y, Cai Y, Zhang F, Xia G, Xiang F (2010). "Cloning and functional analysis of geraniol 10-hydroxylase, a cytochrome P450 from Swertia mussotii Franch". Bioscience, Biotechnology, and Biochemistry. 74 (8): 1583–90. doi:10.1271/bbb.100175. PMID 20699579.
- Sung PH, Huang FC, Do YY, Huang PL (May 2011). "Functional expression of geraniol 10-hydroxylase reveals its dual function in the biosynthesis of terpenoid and phenylpropanoid". Journal of Agricultural and Food Chemistry. 59 (9): 4637–43. doi:10.1021/jf200259n. PMID 21504162.
External links
- Geraniol+8-hydroxylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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