ADCY8

Adenylyl cyclase type 8 is an enzyme that in humans is encoded by the ADCY8 gene.[4][5]

ADCY8
Identifiers
Aliases	ADCY8, AC8, ADCY3, HBAC1, adenylate cyclase 8 (brain), adenylate cyclase 8
External IDs	OMIM: 103070 MGI: 1341110 HomoloGene: 37443 GeneCards: ADCY8
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.22 Start 130,780,301 bp[1] End 131,040,909 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • metal ion binding • lyase activity • adenylate cyclase activity • phosphorus-oxygen lyase activity • calcium- and calmodulin-responsive adenylate cyclase activity • ATP binding • guanylate cyclase activity • actin binding • calmodulin binding • protein homodimerization activity • protein heterodimerization activity • protein dimerization activity • protein phosphatase 2A binding Cellular component • integral component of membrane • membrane • cell membrane • guanylate cyclase complex, soluble • Schaffer collateral - CA1 synapse • hippocampal mossy fiber to CA3 synapse • glutamatergic synapse • integral component of presynaptic membrane • intracellular • integral component of plasma membrane • caveola • clathrin-coated pit • GO:0097483, GO:0097481 postsynaptic density • actin cytoskeleton • basolateral plasma membrane • apical plasma membrane • axon • dendrite • neuronal cell body membrane • plasma membrane raft • membrane raft • presynaptic active zone • excitatory synapse • cell junction • clathrin-coated vesicle membrane • cytoplasmic vesicle • presynaptic membrane • cell projection • synapse • postsynaptic membrane Biological process • cAMP biosynthetic process • GO:0007243 intracellular signal transduction • cellular response to glucagon stimulus • cyclic nucleotide biosynthetic process • long-term memory • renal water homeostasis • learning or memory • signal transduction • cGMP biosynthetic process • adenylate cyclase-activating G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway • modulation of chemical synaptic transmission • positive regulation of cytosolic calcium ion concentration • memory • locomotory behavior • glucose mediated signaling pathway • positive regulation of synaptic plasticity • positive regulation of CREB transcription factor activity • activation of protein kinase A activity • positive regulation of insulin secretion involved in cellular response to glucose stimulus • opioid receptor signaling pathway • glucose homeostasis • protein oligomerization • protein homooligomerization • regulation of cytosolic calcium ion concentration • cellular response to calcium ion • cellular response to morphine • cellular response to glucose stimulus • regulation of cellular response to stress • neuroinflammatory response • positive regulation of long-term synaptic potentiation • positive regulation of long term synaptic depression • cellular response to forskolin • activation of adenylate cyclase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114	11514
Ensembl	ENSG00000155897	n/a
UniProt	P40145 Q4F7X0	P97490
RefSeq (mRNA)	NM_001115	NM_001291903 NM_009623 NM_001331075
RefSeq (protein)	NP_001106 NP_001106.1	NP_001278832 NP_001318004 NP_033753
Location (UCSC)	Chr 8: 130.78 – 131.04 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (R_s and R_i) interact with G proteins (G_s and G_i) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000155897 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Defer N, Marinx O, Stengel D, Danisova A, Iourgenko V, Matsuoka I, Caput D, Hanoune J (Aug 1994). "Molecular cloning of the human type VIII adenylyl cyclase". FEBS Letters. 351 (1): 109–13. doi:10.1016/0014-5793(94)00836-1. PMID 8076676.
5. "Entrez Gene: ADCY8 adenylate cyclase 8 (brain)".

External links

• Human ADCY3 genome location and ADCY3 gene details page in the UCSC Genome Browser.
• Human ADCY8 genome location and ADCY8 gene details page in the UCSC Genome Browser.

Further reading

• Stengel D, Parma J, Gannagé MH, Roeckel N, Mattei MG, Barouki R, Hanoune J (1992). "Different chromosomal localization of two adenylyl cyclase genes expressed in human brain". Human Genetics. 90 (1–2): 126–30. doi:10.1007/BF00210755. PMID 1427768.
• Parma J, Stengel D, Gannage MH, Poyard M, Barouki R, Hanoune J (Aug 1991). "Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain". Biochemical and Biophysical Research Communications. 179 (1): 455–62. doi:10.1016/0006-291X(91)91392-P. PMID 1715695.
• Cali JJ, Zwaagstra JC, Mons N, Cooper DM, Krupinski J (Apr 1994). "Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain". The Journal of Biological Chemistry. 269 (16): 12190–5. PMID 8163524.
• Gu C, Cooper DM (Mar 1999). "Calmodulin-binding sites on adenylyl cyclase type VIII". The Journal of Biological Chemistry. 274 (12): 8012–21. doi:10.1074/jbc.274.12.8012. PMID 10075700.
• Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (Mar 1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Archiv. 437 (4): 538–46. doi:10.1007/s004240050815. PMID 10089566.
• Speth C, Joebstl B, Barcova M, Dierich MP (Apr 2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–36. doi:10.1097/00002030-200004140-00001. PMID 10807185.
• Patke CL, Shearer WT (May 2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". The Journal of Allergy and Clinical Immunology. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Patrizio M, Colucci M, Levi G (Apr 2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". Journal of Neurochemistry. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302.
• Parkinson NA, Bolsover SR (Jul 2001). "A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones". Brain Research. Molecular Brain Research. 91 (1–2): 43–9. doi:10.1016/S0169-328X(01)00119-X. PMID 11457491.
• Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP (Apr 2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". Journal of Virology. 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041. PMID 11884542.
• Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". Journal of Receptor and Signal Transduction Research. 22 (1–4): 79–110. doi:10.1081/RRS-120014589. PMID 12503609.
• Georget M, Mateo P, Vandecasteele G, Lipskaia L, Defer N, Hanoune J, Hoerter J, Lugnier C, Fischmeister R (Aug 2003). "Cyclic AMP compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8)". FASEB Journal. 17 (11): 1380–91. doi:10.1096/fj.02-0784com. PMID 12890691.
• Crossthwaite AJ, Ciruela A, Rayner TF, Cooper DM (Feb 2006). "A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A". Molecular Pharmacology. 69 (2): 608–17. doi:10.1124/mol.105.018275. PMID 16258073.
• Simpson RE, Ciruela A, Cooper DM (Jun 2006). "The role of calmodulin recruitment in Ca2+ stimulation of adenylyl cyclase type 8". The Journal of Biological Chemistry. 281 (25): 17379–89. doi:10.1074/jbc.M510992200. PMID 16613843.
• Nlend MC, Schmid A, Sutto Z, Ransford GA, Conner GE, Fregien N, Salathe M (Jul 2007). "Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia". FEBS Letters. 581 (17): 3241–6. doi:10.1016/j.febslet.2007.06.015. PMC 1986749. PMID 17586501.