GUCY1A3

Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene.[5][6]

GUCY1A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3UVJ, 4NI2
Identifiers
Aliases	GUCY1A1, GC-SA3, GUC1A3, GUCA3, GUCSA3, MYMY6, guanylate cyclase 1, soluble, alpha 3, guanylate cyclase 1 soluble subunit alpha, guanylate cyclase 1 soluble subunit alpha 1, GUCY1A3
External IDs	OMIM: 139396 MGI: 1926562 HomoloGene: 37360 GeneCards: GUCY1A1
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q32.1 Start 155,666,711 bp[1] End 155,732,349 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E3 Start 82,092,427 bp[2] End 82,145,789 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • guanylate cyclase activity • GTP binding • GO:0001948 protein binding • heme binding • lyase activity • phosphorus-oxygen lyase activity • signaling receptor activity • adenylate cyclase activity Cellular component • cytoplasm • cell membrane • guanylate cyclase complex, soluble • glutamatergic synapse • GABA-ergic synapse Biological process • GO:0007243 intracellular signal transduction • cyclic nucleotide biosynthetic process • blood circulation • regulation of blood pressure • cGMP biosynthetic process • relaxation of vascular smooth muscle • nitric oxide mediated signal transduction • positive regulation of nitric oxide mediated signal transduction • retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2982	60596
Ensembl	ENSG00000164116	ENSMUSG00000033910
UniProt	Q02108 Q6PJR4	Q9ERL9
RefSeq (mRNA)	NM_000856 NM_001130682 NM_001130683 NM_001130684 NM_001130685 NM_001130686 NM_001130687 NM_001256449	NM_021896 NM_001356987 NM_001356988
RefSeq (protein)	NP_000847 NP_001124154 NP_001124155 NP_001124156 NP_001124157 NP_001124159 NP_001243378 NP_001366595 NP_001366596 NP_001366597 NP_001366598 NP_001366599 NP_001366600 NP_001366601 NP_001366602 NP_001366603 NP_001366604 NP_001366605	NP_068696 NP_001343916 NP_001343917
Location (UCSC)	Chr 4: 155.67 – 155.73 Mb	Chr 3: 82.09 – 82.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.[6] Mutations in this gene have been associated to cases of myocardial infarction (10.1038/nature12722).

References

1. GRCh38: Ensembl release 89: ENSG00000164116 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033910 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Giuili G, Scholl U, Bulle F, Guellaen G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett. 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257.
6. "Entrez Gene: GUCY1A3 guanylate cyclase 1, soluble, alpha 3".

Further reading

• Giuili G, Roechel N, Scholl U, et al. (1993). "Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33". Hum. Genet. 91 (3): 257–60. doi:10.1007/BF00218267. PMID 8097486.
• Papapetropoulos A, Cziraki A, Rubin JW, et al. (1996). "cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue". J. Cell. Physiol. 167 (2): 213–21. doi:10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S. PMID 8613461.
• Zabel U, Weeger M, La M, Schmidt HH (1998). "Human soluble guanylate cyclase: functional expression and revised isoenzyme family". Biochem. J. 335 (1): 51–7. PMC 1219751. PMID 9742212.
• Zhou Y, Zheng JB, Gu X, et al. (2000). "A novel Pax-6 binding site in rodent B1 repetitive elements: coevolution between developmental regulation and repeated elements?". Gene. 245 (2): 319–28. doi:10.1016/S0378-1119(00)00019-6. PMID 10717483.
• Behrends S, Vehse K, Scholz H, et al. (2000). "Assignment of GUCY1A3, a candidate gene for hypertension, to human chromosome bands 4q31.1→q31.2 by in situ hybridization". Cytogenet. Cell Genet. 88 (3–4): 204–5. doi:10.1159/000015548. PMID 10828587.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Saino M, Maruyama T, Sekiya T, et al. (2005). "Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3". Oncol. Rep. 12 (1): 47–52. doi:10.3892/or.12.1.47. PMID 15201957.
• Meurer S, Pioch S, Wagner K, et al. (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–54. doi:10.1074/jbc.M410565200. PMID 15381706.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.