ADCY10

Adenylyl cyclase 10 also known as ADCY10 is an enzyme that, in humans, is encoded by the ADCY10 gene.[5]

ADCY10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CLK, 4CLL, 4CLP, 4CLS, 4CLT, 4CLU, 4CLW, 4CLY, 4CLZ, 4CM0, 4CM2, 4OYA, 4OYB, 4OYI, 4OYM, 4OYO, 4OYP, 4OYW, 4OYX, 4OYZ, 4OZ2, 4OZ3, 4UST, 4USU, 4USV, 4USW, 5D0R
Identifiers
Aliases	ADCY10, HCA2, SAC, SACI, Sacy, hsAC, HEL-S-7a, adenylate cyclase 10 (soluble), adenylate cyclase 10, soluble, adenylate cyclase 10
External IDs	OMIM: 605205 MGI: 2660854 HomoloGene: 10188 GeneCards: ADCY10
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.2 Start 167,809,386 bp[1] End 167,914,215 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H2.2-H2.3 Start 165,485,183 bp[2] End 165,576,774 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • manganese ion binding • metal ion binding • lyase activity • adenylate cyclase activity • phosphorus-oxygen lyase activity • bicarbonate binding • ATP binding • magnesium ion binding • ATPase binding Cellular component • cytoplasm • cytosol • cell projection • membrane • microtubule cytoskeleton • growth cone • basal part of cell • cell membrane • apical part of cell • cilium • axon • neuronal cell body • dendrite • mitochondrion • perinuclear region of cytoplasm • motile cilium • cytoskeleton • cell nucleus • apical plasma membrane • extracellular region Biological process • cellular response to inorganic substance • GO:0007243 intracellular signal transduction • epithelial cilium movement • cyclic nucleotide biosynthetic process • spermatogenesis • positive regulation of apoptotic process • cAMP biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55811	271639
Ensembl	ENSG00000143199	ENSMUSG00000026567
UniProt	Q96PN6	Q8C0T9
RefSeq (mRNA)	NM_001167749 NM_001297772 NM_018417	NM_173029 NM_001357427
RefSeq (protein)	NP_001161221 NP_001284701 NP_060887	NP_766617 NP_001344356
Location (UCSC)	Chr 1: 167.81 – 167.91 Mb	Chr 1: 165.49 – 165.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction.[6]

Clinical significance

Mutations in the ADCY10 gene are associated with an increased risk of adsorptive hypercalciuria.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000143199 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026567 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reed BY, Heller HJ, Gitomer WL, Pak CY (November 1999). "Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3-q24". J. Clin. Endocrinol. Metab. 84 (11): 3907–13. doi:10.1210/jc.84.11.3907. PMID 10566627.
6. "Entrez Gene: ADCY10".

External links

• Human ADCY10 genome location and ADCY10 gene details page in the UCSC Genome Browser.

Further reading

• Wuttke MS, Buck J, Levin LR (2002). "Bicarbonate-regulated soluble adenylyl cyclase". JOP. 2 (4 Suppl): 154–8. PMID 11875252.
• Hukovic N, Panetta R, Kumar U, et al. (1998). "The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization". J. Biol. Chem. 273 (33): 21416–22. doi:10.1074/jbc.273.33.21416. PMID 9694905.
• Buck J, Sinclair ML, Schapal L, et al. (1999). "Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals". Proc. Natl. Acad. Sci. U.S.A. 96 (1): 79–84. doi:10.1073/pnas.96.1.79. PMC 15096. PMID 9874775.
• Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). "The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling". J. Biol. Chem. 274 (34): 23707–18. doi:10.1074/jbc.274.34.23707. PMID 10446129.
• Sinclair ML, Wang XY, Mattia M, et al. (2000). "Specific expression of soluble adenylyl cyclase in male germ cells". Mol. Reprod. Dev. 56 (1): 6–11. doi:10.1002/(SICI)1098-2795(200005)56:1<6::AID-MRD2>3.0.CO;2-M. PMID 10737962.
• Chen Y, Cann MJ, Litvin TN, et al. (2000). "Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor". Science. 289 (5479): 625–8. doi:10.1126/science.289.5479.625. PMID 10915626.
• Jaiswal BS, Conti M (2001). "Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase". J. Biol. Chem. 276 (34): 31698–708. doi:10.1074/jbc.M011698200. PMID 11423534.
• Reed BY, Gitomer WL, Heller HJ, et al. (2002). "Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density". J. Clin. Endocrinol. Metab. 87 (4): 1476–85. doi:10.1210/jc.87.4.1476. PMID 11932268.
• Zippin JH, Chen Y, Nahirney P, et al. (2003). "Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains". FASEB J. 17 (1): 82–4. doi:10.1096/fj.02-0598fje. PMID 12475901.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Litvin TN, Kamenetsky M, Zarifyan A, et al. (2003). "Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate". J. Biol. Chem. 278 (18): 15922–6. doi:10.1074/jbc.M212475200. PMID 12609998.
• Jaiswal BS, Conti M (2003). "Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 100 (19): 10676–81. doi:10.1073/pnas.1831008100. PMC 196863. PMID 12958208.
• Marjanovic JA, Li Z, Stojanovic A, Du X (2006). "Stimulatory roles of nitric-oxide synthase 3 and guanylyl cyclase in platelet activation". J. Biol. Chem. 280 (45): 37430–8. doi:10.1074/jbc.M506518200. PMID 16144836.
• Schmid A, Sutto Z, Nlend MC, et al. (2007). "Soluble Adenylyl Cyclase Is Localized to Cilia and Contributes to Ciliary Beat Frequency Regulation via Production of cAMP". J. Gen. Physiol. 130 (1): 99–109. doi:10.1085/jgp.200709784. PMC 2154360. PMID 17591988.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.