ADCY1

Adenylyl cyclase type 1 is an enzyme that in humans is encoded by the ADCY1 gene.[5][6]

ADCY1
Identifiers
Aliases	ADCY1, AC1, DFNB44, adenylate cyclase 1 (brain), adenylate cyclase 1
External IDs	OMIM: 103072 MGI: 99677 HomoloGene: 41419 GeneCards: ADCY1
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p12.3 Start 45,574,140 bp[1] End 45,723,116 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A1|11 4.72 cM Start 7,063,489 bp[2] End 7,178,506 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • metal ion binding • calmodulin binding • lyase activity • phosphorus-oxygen lyase activity • ATP binding • adenylate cyclase activity • guanylate cyclase activity • calcium- and calmodulin-responsive adenylate cyclase activity Cellular component • cytoplasm • integral component of membrane • membrane • cell membrane • integral component of plasma membrane • membrane raft • extracellular exosome • cell nucleus • guanylate cyclase complex, soluble • GO:0097483, GO:0097481 postsynaptic density • Schaffer collateral - CA1 synapse • hippocampal mossy fiber to CA3 synapse • glutamatergic synapse • integral component of postsynaptic density membrane Biological process • cellular response to calcium ion • activation of protein kinase A activity • GO:0007243 intracellular signal transduction • cellular response to forskolin • axonogenesis • rhythmic process • cellular response to glucagon stimulus • cyclic nucleotide biosynthetic process • response to lithium ion • long-term memory • regulation of circadian rhythm • circadian rhythm • renal water homeostasis • response to drug • activation of adenylate cyclase activity • cAMP biosynthetic process • cGMP biosynthetic process • signal transduction • adenylate cyclase-activating G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • cAMP-mediated signaling • G-protein coupled receptor signaling pathway • brain development • positive regulation of CREB transcription factor activity • modulation of chemical synaptic transmission • neuroinflammatory response • positive regulation of long-term synaptic potentiation • regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	107	432530
Ensembl	ENSG00000164742	ENSMUSG00000020431
UniProt	Q08828	O88444
RefSeq (mRNA)	NM_001281768 NM_021116	NM_009622
RefSeq (protein)	NP_001268697 NP_066939	NP_033752
Location (UCSC)	Chr 7: 45.57 – 45.72 Mb	Chr 11: 7.06 – 7.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a form of adenylyl cyclase expressed in the brain. A similar protein in mice is involved in pattern formation of the brain.[6]

Function

ADCY1 is a calmodulin-sensitive adenylyl cyclase. In terms of function, It may be involved in regulatory processes in the central nervous system; specifically, it may play a role in memory acquisition and learning. It is inhibited by the G protein beta and gamma subunit complex.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000164742 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020431 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Villacres EC, Xia Z, Bookbinder LH, Edelhoff S, Disteche CM, Storm DR (May 1993). "Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase". Genomics. 16 (2): 473–8. doi:10.1006/geno.1993.1213. PMID 8314585.
6. "Entrez Gene: ADCY1 adenylyl cyclase 1 (brain)".
7. "Gene Cards: ADCY1 Gene". Retrieved 2012-12-30.

External links

• Human ADCY1 genome location and ADCY1 gene details page in the UCSC Genome Browser.

Further reading

• Osawa S, Dhanasekaran N, Woon CW, Johnson GL (Nov 1990). "G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions". Cell. 63 (4): 697–706. doi:10.1016/0092-8674(90)90136-3. PMID 2121366.
• Gaudin C, Homcy CJ, Ishikawa Y (Nov 1994). "Mammalian adenylyl cyclase family members are randomly located on different chromosomes". Human Genetics. 94 (5): 527–9. doi:10.1007/BF00211020. PMID 7959689.
• Whisnant RE, Gilman AG, Dessauer CW (Jun 1996). "Interaction of the two cytosolic domains of mammalian adenylyl cyclase". Proceedings of the National Academy of Sciences of the United States of America. 93 (13): 6621–5. Bibcode:1996PNAS...93.6621W. doi:10.1073/pnas.93.13.6621. PMC 39075. PMID 8692867.
• Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (Mar 1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Archiv. 437 (4): 538–46. doi:10.1007/s004240050815. PMID 10089566.
• Speth C, Joebstl B, Barcova M, Dierich MP (Apr 2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–36. doi:10.1097/00002030-200004140-00001. PMID 10807185.
• Patke CL, Shearer WT (May 2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". The Journal of Allergy and Clinical Immunology. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
• Patrizio M, Colucci M, Levi G (Apr 2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". Journal of Neurochemistry. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302.
• Côté M, Guillon G, Payet MD, Gallo-Payet N (Sep 2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland". The Journal of Clinical Endocrinology and Metabolism. 86 (9): 4495–503. doi:10.1210/jc.86.9.4495. PMID 11549699.
• Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP (Apr 2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". Journal of Virology. 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041. PMID 11884542.
• Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". Journal of Receptor and Signal Transduction Research. 22 (1–4): 79–110. doi:10.1081/RRS-120014589. PMID 12503609.
• Tucholski J, Johnson GV (Jul 2003). "Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation". The Journal of Biological Chemistry. 278 (29): 26838–43. doi:10.1074/jbc.M303683200. PMID 12743114.
• Wang H, Ferguson GD, Pineda VV, Cundiff PE, Storm DR (Jun 2004). "Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP". Nature Neuroscience. 7 (6): 635–42. doi:10.1038/nn1248. PMID 15133516.
• Vortherms TA, Nguyen CH, Berlot CH, Watts VJ (Dec 2004). "Using molecular tools to dissect the role of Galphas in sensitization of AC1". Molecular Pharmacology. 66 (6): 1617–24. doi:10.1124/mol.104.000166. PMID 15361543.
• Weber B, Schaper C, Scholz J, Bein B, Rodde C, H Tonner P (Oct 2006). "Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase". Cellular Signalling. 18 (10): 1748–57. doi:10.1016/j.cellsig.2006.01.017. PMID 16531006.
• Nlend MC, Schmid A, Sutto Z, Ransford GA, Conner GE, Fregien N, Salathe M (Jul 2007). "Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia". FEBS Letters. 581 (17): 3241–6. doi:10.1016/j.febslet.2007.06.015. PMC 1986749. PMID 17586501.