ADCY6

Adenylyl cyclase type 6 is an enzyme that in humans is encoded by the ADCY6 gene.[5]

ADCY6
Identifiers
Aliases	ADCY6, AC6, LCCS8, adenylate cyclase 6
External IDs	OMIM: 600294 MGI: 87917 HomoloGene: 22400 GeneCards: ADCY6
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 48,766,194 bp[1] End 48,789,037 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 F1 Start 98,589,973 bp[2] End 98,610,076 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • nucleotide binding • lyase activity • protein kinase binding • adenylate cyclase activity • phosphorus-oxygen lyase activity • ATP binding • GO:0001948 protein binding • guanylate cyclase activity • protein kinase C binding Cellular component • integral component of membrane • cell projection • intrinsic component of plasma membrane • membrane • cilium • cell membrane • guanylate cyclase complex, soluble • intracellular • integral component of plasma membrane • stereocilium Biological process • negative regulation of neuron projection development • GO:0007243 intracellular signal transduction • cAMP biosynthetic process • cellular response to forskolin • negative regulation of urine volume • cellular response to glucagon stimulus • cyclic nucleotide biosynthetic process • cellular response to vasopressin • cellular response to catecholamine stimulus • cellular response to prostaglandin E stimulus • dopamine receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway • renal water homeostasis • cGMP biosynthetic process • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • regulation of blood vessel diameter • G-protein coupled receptor signaling pathway • activation of adenylate cyclase activity • activation of protein kinase A activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	112	11512
Ensembl	ENSG00000174233	ENSMUSG00000022994
UniProt	O43306	Q01341
RefSeq (mRNA)	NM_015270 NM_020983	NM_007405 NM_001368413
RefSeq (protein)	NP_056085	NP_031431 NP_001355342
Location (UCSC)	Chr 12: 48.77 – 48.79 Mb	Chr 15: 98.59 – 98.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes adenylyl cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000174233 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022994 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ADCY6 adenylate cyclase 6".

External links

• Human ADCY6 genome location and ADCY6 gene details page in the UCSC Genome Browser.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Gaudin C, Homcy CJ, Ishikawa Y (1994). "Mammalian adenylyl cyclase family members are randomly located on different chromosomes". Hum. Genet. 94 (5): 527–9. doi:10.1007/BF00211020. PMID 7959689.
• Haber N, Stengel D, Defer N, et al. (1994). "Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI". Hum. Genet. 94 (1): 69–73. doi:10.1007/BF02272844. PMID 8034296.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Harry A, Chen Y, Magnusson R, et al. (1997). "Differential regulation of adenylyl cyclases by Galphas". J. Biol. Chem. 272 (30): 19017–21. doi:10.1074/jbc.272.30.19017. PMID 9228084.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Mhaouty-Kodja S, Bouet-Alard R, Limon-Boulez I, et al. (1998). "Molecular diversity of adenylyl cyclases in human and rat myometrium. Correlation with global adenylyl cyclase activity during mid- and term pregnancy". J. Biol. Chem. 272 (49): 31100–6. doi:10.1074/jbc.272.49.31100. PMID 9388262.
• Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
• Leech CA, Castonguay MA, Habener JF (1999). "Expression of adenylyl cyclase subtypes in pancreatic beta-cells". Biochem. Biophys. Res. Commun. 254 (3): 703–6. doi:10.1006/bbrc.1998.9906. PMID 9920805.
• Barcova M, Speth C, Kacani L, et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Arch. 437 (4): 538–46. doi:10.1007/s004240050815. PMID 10089566.
• Raimundo S, Giray J, Volff JN, et al. (1999). "Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues". Clin. Chim. Acta. 285 (1–2): 155–61. doi:10.1016/S0009-8981(99)00067-4. PMID 10481931.
• Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–36. doi:10.1097/00002030-200004140-00001. PMID 10807185.
• Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". J. Allergy Clin. Immunol. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
• Wicker R, Catalan AG, Cailleux A, et al. (2000). "Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues". Biochim. Biophys. Acta. 1493 (1–2): 279–83. doi:10.1016/s0167-4781(00)00187-1. PMID 10978539.
• Vanvooren V, Allgeier A, Cosson E, et al. (2001). "Expression of multiple adenylyl cyclase isoforms in human and dog thyroid". Mol. Cell. Endocrinol. 170 (1–2): 185–96. doi:10.1016/S0303-7207(00)00322-1. PMID 11162902.
• Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302.
• Côté M, Guillon G, Payet MD, Gallo-Payet N (2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland". J. Clin. Endocrinol. Metab. 86 (9): 4495–503. doi:10.1210/jc.86.9.4495. PMID 11549699.
• Speth C, Schabetsberger T, Mohsenipour I, et al. (2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". J. Virol. 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041. PMID 11884542.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.