ADCY3

Adenylyl cyclase type 3 is an enzyme that in humans is encoded by the ADCY3 gene.[5][6]

ADCY3
Identifiers
Aliases	ADCY3, AC3, AC-III, adenylate cyclase 3, BMIQ19
External IDs	OMIM: 600291 MGI: 99675 HomoloGene: 2978 GeneCards: ADCY3
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 24,819,169 bp[1] End 24,919,839 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.1 Start 4,133,103 bp[2] End 4,213,525 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • metal ion binding • calmodulin binding • lyase activity • phosphorus-oxygen lyase activity • ATP binding • adenylate cyclase activity • guanylate cyclase activity Cellular component • cytoplasm • integral component of membrane • Golgi apparatus • cell projection • membrane • cell membrane • integral component of plasma membrane • cilium • guanylate cyclase complex, soluble Biological process • cAMP biosynthetic process • activation of protein kinase A activity • GO:0007243 intracellular signal transduction • response to stimulus • cellular response to glucagon stimulus • cyclic nucleotide biosynthetic process • sensory perception of smell • renal water homeostasis • signal transduction • activation of adenylate cyclase activity • cGMP biosynthetic process • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway • single fertilization • acrosome reaction • olfactory learning • flagellated sperm motility • cellular response to forskolin • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	109	104111
Ensembl	ENSG00000138031	ENSMUSG00000020654
UniProt	O60266	Q8VHH7
RefSeq (mRNA)	NM_004036 NM_001320613 NM_001377128 NM_001377129 NM_001377130 NM_001377131 NM_001377132	NM_001159536 NM_001159537 NM_138305
RefSeq (protein)	NP_001307542 NP_004027 NP_001364057 NP_001364058 NP_001364059 NP_001364060 NP_001364061	NP_001153008 NP_001153009 NP_612178
Location (UCSC)	Chr 2: 24.82 – 24.92 Mb	Chr 12: 4.13 – 4.21 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes adenylyl cyclase 3, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP).[6]

The ADCY3 subtype likely mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000138031 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020654 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yang B, He B, Abdel-Halim SM, Tibell A, Brendel MD, Bretzel RG, Efendic S, Hillert J (Jan 1999). "Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets". Biochemical and Biophysical Research Communications. 254 (3): 548–551. doi:10.1006/bbrc.1998.9983. PMID 9920776.
6. "Entrez Gene: ADCY3 adenylate cyclase 3".
7. "Gene Cards: ADCY3 Gene". Retrieved 2012-12-30.

External links

• Human ADCY3 genome location and ADCY3 gene details page in the UCSC Genome Browser.

Further reading

• Gaudin C, Homcy CJ, Ishikawa Y (Nov 1994). "Mammalian adenylyl cyclase family members are randomly located on different chromosomes". Human Genetics. 94 (5): 527–9. doi:10.1007/BF00211020. PMID 7959689.
• Haber N, Stengel D, Defer N, Roeckel N, Mattei MG, Hanoune J (Jul 1994). "Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI". Human Genetics. 94 (1): 69–73. doi:10.1007/BF02272844. PMID 8034296.
• Hellevuo K, Yoshimura M, Kao M, Hoffman PL, Cooper DM, Tabakoff B (Apr 1993). "A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line". Biochemical and Biophysical Research Communications. 192 (1): 311–318. doi:10.1006/bbrc.1993.1415. PMID 8476432.
• Wei J, Wayman G, Storm DR (Sep 1996). "Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo". The Journal of Biological Chemistry. 271 (39): 24231–24235. doi:10.1074/jbc.271.39.24231. PMID 8798667.
• Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–39. doi:10.1093/dnares/5.1.31. PMID 9628581.
• Wei J, Zhao AZ, Chan GC, Baker LP, Impey S, Beavo JA, Storm DR (Sep 1998). "Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals". Neuron. 21 (3): 495–504. doi:10.1016/S0896-6273(00)80561-9. PMID 9768837.
• Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (Mar 1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Archiv. 437 (4): 538–546. doi:10.1007/s004240050815. PMID 10089566.
• Speth C, Joebstl B, Barcova M, Dierich MP (Apr 2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–636. doi:10.1097/00002030-200004140-00001. PMID 10807185.
• Patke CL, Shearer WT (May 2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". The Journal of Allergy and Clinical Immunology. 105 (5): 975–982. doi:10.1067/mai.2000.105315. PMID 10808179.
• Vanvooren V, Allgeier A, Cosson E, Van Sande J, Defer N, Pirlot M, Hanoune J, Dumont JE (Dec 2000). "Expression of multiple adenylyl cyclase isoforms in human and dog thyroid". Molecular and Cellular Endocrinology. 170 (1–2): 185–196. doi:10.1016/S0303-7207(00)00322-1. PMID 11162902.
• Patrizio M, Colucci M, Levi G (Apr 2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". Journal of Neurochemistry. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302.
• Côté M, Guillon G, Payet MD, Gallo-Payet N (Sep 2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland". The Journal of Clinical Endocrinology and Metabolism. 86 (9): 4495–4503. doi:10.1210/jc.86.9.4495. PMID 11549699.
• Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP (Apr 2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". Journal of Virology. 76 (7): 3179–3188. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041. PMID 11884542.
• Kobayakawa K, Hayashi R, Morita K, Miyamichi K, Oka Y, Tsuboi A, Sakano H (Jul 2002). "Stomatin-related olfactory protein, SRO, specifically expressed in the murine olfactory sensory neurons". The Journal of Neuroscience. 22 (14): 5931–7. PMID 12122055.
• Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". Journal of Receptor and Signal Transduction Research. 22 (1–4): 79–110. doi:10.1081/RRS-120014589. PMID 12503609.
• Katsel PL, Tagliente TM, Schwarz TE, Craddock-Royal BD, Patel ND, Maayani S (Feb 2003). "Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human platelets" (PDF). Platelets. 14 (1): 21–33. doi:10.1080/0953710021000062905. PMID 12623444.
• Celano M, Arturi F, Presta I, Bruno R, Scarpelli D, Calvagno MG, Cristofaro C, Bulotta S, Giannasio P, Sacco R, Filetti S, Russo D (May 2003). "Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules". Molecular and Cellular Endocrinology. 203 (1–2): 129–135. doi:10.1016/S0303-7207(03)00086-8. PMID 12782409.