ADCY4

Adenylyl cyclase type 4 is an enzyme that in humans is encoded by the ADCY4 gene.[5][6]

ADCY4
Identifiers
Aliases	ADCY4, AC4, adenylate cyclase 4
External IDs	OMIM: 600292 MGI: 99674 HomoloGene: 23149 GeneCards: ADCY4
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 24,318,349 bp[1] End 24,335,093 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C3 Start 55,769,057 bp[2] End 55,784,095 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • metal ion binding • GO:0001948 protein binding • lyase activity • phosphorus-oxygen lyase activity • ATP binding • guanylate cyclase activity • protein kinase C binding • adenylate cyclase activity Cellular component • cytoplasm • integral component of membrane • membrane • cell membrane • intracellular • dendrite • guanylate cyclase complex, soluble • integral component of plasma membrane Biological process • GO:0007243 intracellular signal transduction • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • cellular response to glucagon stimulus • cyclic nucleotide biosynthetic process • renal water homeostasis • cAMP biosynthetic process • cGMP biosynthetic process • signal transduction • adenylate cyclase-activating G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway • activation of adenylate cyclase activity • activation of protein kinase A activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	196883	104110
Ensembl	ENSG00000129467 ENSG00000284814	ENSMUSG00000022220
UniProt	Q8NFM4	Q91WF3
RefSeq (mRNA)	NM_139247 NM_001198568 NM_001198592	NM_080435 NM_001361604
RefSeq (protein)	NP_001185497 NP_001185521 NP_640340	NP_536683 NP_001348533
Location (UCSC)	Chr 14: 24.32 – 24.34 Mb	Chr 14: 55.77 – 55.78 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the family of adenylyl cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylyl cyclase 4, along with adenylyl cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylyl cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals.[6]

References

1. ENSG00000284814 GRCh38: Ensembl release 89: ENSG00000129467, ENSG00000284814 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022220 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Edelhoff S, Villacres EC, Storm DR, Disteche CM (Jul 1995). "Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse". Mamm Genome. 6 (2): 111–3. doi:10.1007/BF00303253. PMID 7766992.
6. "Entrez Gene: ADCY4 adenylate cyclase 4".

External links

• Human ADCY4 genome location and ADCY4 gene details page in the UCSC Genome Browser.

Further reading

• Gaudin C, Homcy CJ, Ishikawa Y (1994). "Mammalian adenylyl cyclase family members are randomly located on different chromosomes". Hum. Genet. 94 (5): 527–9. doi:10.1007/BF00211020. PMID 7959689.
• Barcova M, Speth C, Kacani L, et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Arch. 437 (4): 538–46. doi:10.1007/s004240050815. PMID 10089566.
• Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–36. doi:10.1097/00002030-200004140-00001. PMID 10807185.
• Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". J. Allergy Clin. Immunol. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
• Wong ST, Trinh K, Hacker B, et al. (2000). "Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice". Neuron. 27 (3): 487–97. doi:10.1016/S0896-6273(00)00060-X. PMID 11055432.
• Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302.
• Côté M, Guillon G, Payet MD, Gallo-Payet N (2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland". J. Clin. Endocrinol. Metab. 86 (9): 4495–503. doi:10.1210/jc.86.9.4495. PMID 11549699.
• Speth C, Schabetsberger T, Mohsenipour I, et al. (2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". J. Virol. 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041. PMID 11884542.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". J. Recept. Signal Transduct. Res. 22 (1–4): 79–110. doi:10.1081/RRS-120014589. PMID 12503609.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.