Channel-conductance-controlling ATPase

In enzymology, a channel-conductance-controlling ATPase (EC 3.6.3.49) is an enzyme that catalyzes the chemical reaction

ATP + H2O ADP + phosphate
channel-conductance-controlling ATPase
Identifiers
EC number3.6.3.49
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are ATP and H2O, whereas its two products are ADP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (channel-conductance-controlling).

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1XMI and 1XMJ.

gollark: Probably it would just have to invoke `curl` or something to download the PotatOS For Linux script, and then execute that.
gollark: I should see how small I can make a potatOS installer for Linux.
gollark: I'm writing extremely bad assembly.
gollark: Apparently I can shave off the last 192 bytes and it works effectively the same?
gollark: Indeed.

References

    • Chen M, Zhang JT (1996). "Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes". Mol. Membr. Biol. 13 (1): 33–40. doi:10.3109/09687689609160572. PMID 9147660.
    • Tusnady GE, Bakos E, Varadi A, Sarkadi B (1997). "Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters". FEBS Lett. 402 (1): 1–3. doi:10.1016/S0014-5793(96)01478-0. PMID 9013845.
    • Sheppard DN, Welsh MJ (1999). "Structure and function of the CFTR chloride channel". Physiol. Rev. 79 (1 Suppl): S23–45. doi:10.1152/physrev.1999.79.1.S23. PMID 9922375.


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