Channel-conductance-controlling ATPase
In enzymology, a channel-conductance-controlling ATPase (EC 3.6.3.49) is an enzyme that catalyzes the chemical reaction
- ATP + H2O ADP + phosphate
| channel-conductance-controlling ATPase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.6.3.49 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are ATP and H2O, whereas its two products are ADP and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (channel-conductance-controlling).
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1XMI and 1XMJ.
gollark: What would a GUI add exactly?
gollark: It has its own process manager, sandboxing capabilities, automatic updater, SPUDNET links, etc.
gollark: You aren't seeing the true genius of potatOS however.
gollark: ALL uses simultaneously.
gollark: Energy is disabled. You don't need it.
References
- Chen M, Zhang JT (1996). "Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes". Mol. Membr. Biol. 13 (1): 33–40. doi:10.3109/09687689609160572. PMID 9147660.
- Tusnady GE, Bakos E, Varadi A, Sarkadi B (1997). "Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters". FEBS Lett. 402 (1): 1–3. doi:10.1016/S0014-5793(96)01478-0. PMID 9013845.
- Sheppard DN, Welsh MJ (1999). "Structure and function of the CFTR chloride channel". Physiol. Rev. 79 (1 Suppl): S23–45. doi:10.1152/physrev.1999.79.1.S23. PMID 9922375.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.