Cd2+-exporting ATPase

In enzymology, a Cd2+-exporting ATPase (EC 3.6.3.3) is an enzyme that catalyzes the chemical reaction

ATP + H2O + Cd2+in ADP + phosphate + Cd2+out
cadmium-exporting ATPase
Identifiers
EC number3.6.3.3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The 3 substrates of this enzyme are ATP, H2O, and Cd2+, whereas its 3 products are ADP, phosphate, and Cd2+.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (Cd2+-exporting).

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1MWY, 1MWZ, 2AJ0, and 2AJ1.

gollark: I mean, whatever happens, `nil` won't be a number.
gollark: Why does that matter?
gollark: `type(nil)` == `nil`
gollark: `type(nil)` == [I don't know but it works]
gollark: See, classes tend to just bundle a bunch of state in confusing and annoying ways, along with functions you actually want.

References

    • Silver S, Ji G (1994). "Newer systems for bacterial resistances to toxic heavy metals". Environ. Health Perspect. 102 (Suppl. 3): 107–13. doi:10.2307/3431771. PMC 1567394. PMID 7843081.
    • Tsai KJ, Linet AL (1993). "Formation of a phosphorylated enzyme intermediate by the cadA Cd(2+)-ATPase". Arch. Biochem. Biophys. 305 (2): 267–70. doi:10.1006/abbi.1993.1421. PMID 8373163.


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