ANGPT4

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene.[5][6][7]

ANGPT4
Identifiers
Aliases	ANGPT4, AGP4, ANG-3, ANG4, ANG3, angiopoietin 4
External IDs	OMIM: 603705 MGI: 1336887 HomoloGene: 36302 GeneCards: ANGPT4
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 869,900 bp[1] End 916,334 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 G3|2 74.83 cM Start 151,911,210 bp[2] End 151,945,337 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor tyrosine kinase binding • transmembrane receptor protein tyrosine kinase activator activity Cellular component • extracellular region • extracellular Biological process • Notch signaling pathway • positive regulation of endothelial cell migration • negative regulation of angiogenesis • negative regulation of apoptotic process • negative regulation of blood vessel endothelial cell migration • cellular response to hypoxia • endothelial cell proliferation • angiogenesis • positive regulation of blood vessel endothelial cell migration • leukocyte migration • positive regulation of angiogenesis • positive regulation of peptidyl-tyrosine phosphorylation • activation of transmembrane receptor protein tyrosine kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51378	11602
Ensembl	ENSG00000101280	ENSMUSG00000027460
UniProt	Q9Y264	Q9WVH6
RefSeq (mRNA)	NM_015985 NM_001322809	NM_009641
RefSeq (protein)	NP_001309738 NP_057069	NP_033771
Location (UCSC)	Chr 20: 0.87 – 0.92 Mb	Chr 2: 151.91 – 151.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells.

The protein encoded by this gene functions as an agonist and is an angiopoietin.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000101280 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027460 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD (Apr 1999). "Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans". Proc Natl Acad Sci U S A. 96 (5): 1904–9. doi:10.1073/pnas.96.5.1904. PMC 26709. PMID 10051567.
6. Nishimura M, Miki T, Yashima R, Yokoi N, Yano H, Sato Y, Seino S (May 1999). "Angiopoietin-3, a novel member of the angiopoietin family". FEBS Lett. 448 (2–3): 254–6. doi:10.1016/S0014-5793(99)00381-6. PMID 10218486.
7. "Entrez Gene: ANGPT4 angiopoietin 4".

External links

• Human ANGPT4 genome location and ANGPT4 gene details page in the UCSC Genome Browser.

Further reading

• Grosios K, Leek JP, Markham AF, et al. (1999). "Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3→q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping". Cytogenet. Cell Genet. 84 (1–2): 118–20. doi:10.1159/000015235. PMID 10343124.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Ward EG, Grosios K, Markham AF, Jones PF (2002). "Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2". Cytogenet. Cell Genet. 94 (3–4): 147–54. doi:10.1159/000048807. PMID 11856872.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. doi:10.1007/s100380300025. PMID 12624729.
• Yamakawa M, Liu LX, Belanger AJ, et al. (2004). "Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis". Am. J. Physiol. Renal Physiol. 287 (4): F649–57. doi:10.1152/ajprenal.00028.2004. PMID 15198927.
• Lee HJ, Cho CH, Hwang SJ, et al. (2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200–8. doi:10.1096/fj.03-1466com. PMID 15284220.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Oliner J, Min H, Leal J, et al. (2004). "Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2". Cancer Cell. 6 (5): 507–16. doi:10.1016/j.ccr.2004.09.030. PMID 15542434.
• Olsen MW, Ley CD, Junker N, et al. (2006). "Angiopoietin-4 Inhibits Angiogenesis and Reduces Interstitial Fluid Pressure". Neoplasia. 8 (5): 364–72. doi:10.1593/neo.06127. PMC 1592453. PMID 16790085.