Unsaturated chondroitin disaccharide hydrolase
Unsaturated chondroitin disaccharide hydrolase (EC 3.2.1.180, UGL, unsaturated glucuronyl hydrolase) is an enzyme with systematic name beta-D-4-deoxy-Delta4-GlcAp-(1->3)-beta-D-GalNAc6S hydrolase.[1][2] This enzyme catalyses the following chemical reaction
- beta-D-4-deoxy-Delta4-GlcAp-(1->3)-beta-D-GalNAc6S + H2O 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine-6-O-sulfate
| Unsaturated chondroitin disaccharide hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.1.180 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides.
References
- Maruyama Y, Nakamichi Y, Itoh T, Mikami B, Hashimoto W, Murata K (July 2009). "Substrate specificity of streptococcal unsaturated glucuronyl hydrolases for sulfated glycosaminoglycan". J. Biol. Chem. 284 (27): 18059–69. doi:10.1074/jbc.M109.005660. PMC 2709336. PMID 19416976.
- Nakamichi Y, Maruyama Y, Mikami B, Hashimoto W, Murata K (February 2011). "Structural determinants in streptococcal unsaturated glucuronyl hydrolase for recognition of glycosaminoglycan sulfate groups". J. Biol. Chem. 286 (8): 6262–71. doi:10.1074/jbc.M110.182618. PMC 3057837. PMID 21147778.
External links
- Unsaturated+chondroitin+disaccharide+hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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