GBA3

GBA3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2E9L, 2E9M, 2JFE, 2ZOX, 3VKK
Identifiers
Aliases	GBA3, CBG, CBGL1, GLUC, KLRP, glucosylceramidase beta 3 (gene/pseudogene)
External IDs	OMIM: 606619 GeneCards: GBA3
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	22,819,575 bp[1]
Gene ontology
Molecular function	• beta-galactosidase activity; • glycosylceramidase activity; • hydrolase activity, hydrolyzing O-glycosyl compounds; • beta-glucosidase activity; • hydrolase activity; • hydrolase activity, acting on glycosyl bonds; • scopolin beta-glucosidase activity; • glucosylceramidase activity; • GO:0001948 protein binding; • galactosylceramidase activity;
Cellular component	• cytoplasm; • cytosol; • catalytic complex;
Biological process	• glycosylceramide catabolic process; • metabolism; • glycosphingolipid metabolic process; • glycoside catabolic process; • protein stabilization; • cellular oligosaccharide catabolic process; • positive regulation of exo-alpha-sialidase activity; • carbohydrate metabolic process; • glucosylceramide catabolic process; • galactosylceramide catabolic process; • beta-glucoside catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	57733
	n/a
	ENSG00000249948
	n/a
	Q9H227
	n/a
	NM_001128432; NM_001277225; NM_020973
	n/a
	NP_001121904; NP_001264154; NP_066024
	n/a
	Wikidata
View/Edit Human

Cytosolic beta-glucosidase, also known as cytosolic beta-glucosidase-like protein 1, is a beta-glucosidase (EC 3.2.1.21) enzyme that in humans is encoded by the GBA3 gene.[3][4]

Function

Cytosolic beta-glucosidase is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides.[4] GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a non-lysosomal catabolic pathway of glucosylceramide metabolism.[5]

gollark: I prefer the set dictionaries.

gollark: ``` A language based on the idea of communism. There would be only one great editor (a wiki or similar) and all programmers would write only one big program that does everything. There would be only one datatype that fits everything, so everything belongs to one single class. Functional programming is clearly based on the idea of communism. It elevates functions (things that do the work) to first class citizens, and it is a utopian endeavor aimed at abolishing all states. It is seen as inefficient and unpopular, but always has die-hard defenders, mostly in academia. Besides, ML stands for Marxism-Leninism. Coincidence? I think not. It should be called Soviet Script and the one big program can be called the Universal Soviet Script Repository or USSR for short. And they put all the packages together in one place (Hackage). It already exists and is called 'Web'. It already exists and is called 'Emacs'. Emacs is the one great editor, and the one big program (Emacs can do almost anything). The language is Emacs Lisp, which is functional, and almost everything is a list (the one great datatype/class). Unfortunately```

gollark: It's pronounced Piephoon, by the way.

gollark: Owwww, my eyes.

gollark: I personally use LineageOS, microG and the Yalp play store thing.

References

GRCh38: Ensembl release 89: ENSG00000249948 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: glucosidase".
de Graaf M, van Veen IC, van der Meulen-Muileman IH, Gerritsen WR, Pinedo HM, Haisma HJ (June 2001). "Cloning and characterization of human liver cytosolic beta-glycosidase". Biochem. J. 356 (Pt 3): 907–10. doi:10.1042/0264-6021:3560907. PMC 1221920. PMID 11389701.
Hayashi Y, Okino N, Kakuta Y, Shikanai T, Tani M, Narimatsu H, Ito M (October 2007). "Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase". J. Biol. Chem. 282 (42): 30889–900. doi:10.1074/jbc.M700832200. PMID 17595169.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Cytosolic beta-glucosidase

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000249948 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: glucosidase".

[pmid11389701-4] Graaf M, van Veen IC, van der Meulen-Muileman IH, Gerritsen WR, Pinedo HM, Haisma HJ (June 2001). "Cloning and characterization of human liver cytosolic beta-glycosidase". Biochem. J. 356 (Pt 3): 907–10. doi:10.1042/0264-6021:3560907. PMC 1221920. PMID 11389701.

[pmid17595169-5] Hayashi Y, Okino N, Kakuta Y, Shikanai T, Tani M, Narimatsu H, Ito M (October 2007). "Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase". J. Biol. Chem. 282 (42): 30889–900. doi:10.1074/jbc.M700832200. PMID 17595169.

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

GBA3

Function

See also

References

Further reading

External links