Bacterial neuraminidase

Bacterial neuraminidase is type of neuraminidase and a virulence factor for many bacteria including Bacteroides fragilis and Pseudomonas aeruginosa. Its function is to cleave a sialic acid residue off ganglioside-GM1 (a modulator of cell surface and receptor activity) turning it into asialo-GM1 to which type 4 pili (attachment factors) bind preferentially.

BNR/Asp-box repeat
Structure of a bacterial sialidase.[1]
Identifiers
SymbolBNR
PfamPF02012
Pfam clanCL0434
InterProIPR002860
SCOPe1euu / SUPFAM

References

  1. Gaskell A, Crennell S, Taylor G (November 1995). "The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll". Structure. 3 (11): 1197–205. doi:10.1016/s0969-2126(01)00255-6. PMID 8591030.
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