HPSE2

Heparanase-2 is an enzyme that in humans is encoded by the HPSE2 gene.[5][6]

HPSE2
Identifiers
Aliases	HPSE2, HPA2, HPR2, UFS, UFS1, heparanase 2 (inactive)
External IDs	OMIM: 613469 MGI: 2685814 HomoloGene: 19680 GeneCards: HPSE2
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.2 Start 98,457,077 bp[1] End 99,235,862 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 42,786,539 bp[2] End 43,388,355 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • heparan sulfate proteoglycan binding • heparanase activity • hydrolase activity, acting on glycosyl bonds Cellular component • extracellular region • cell membrane • intracellular • membrane • extracellular matrix Biological process • glycosaminoglycan catabolic process • positive regulation of cell proliferation • extracellular matrix organization • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	60495	545291
Ensembl	ENSG00000172987	ENSMUSG00000074852
UniProt	Q8WWQ2	B2RY83
RefSeq (mRNA)	NM_001166244 NM_001166245 NM_001166246 NM_021828	NM_001081257
RefSeq (protein)	NP_001159716 NP_001159717 NP_001159718 NP_068600	NP_001074726
Location (UCSC)	Chr 10: 98.46 – 99.24 Mb	Chr 19: 42.79 – 43.39 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

It may be associated with urofacial syndrome.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000172987 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074852 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McKenzie E, Tyson K, Stamps A, Smith P, Turner P, Barry R, Hircock M, Patel S, Barry E, Stubberfield C, Terrett J, Page M (Oct 2000). "Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member". Biochem Biophys Res Commun. 276 (3): 1170–7. doi:10.1006/bbrc.2000.3586. PMID 11027606.
6. "Entrez Gene: HPSE2 heparanase 2".
7. Daly SB, Urquhart JE, Hilton E, et al. (June 2010). "Mutations in HPSE2 Cause Urofacial Syndrome". Am J Hum Genet. 86 (6): 963–969. doi:10.1016/j.ajhg.2010.05.006. PMC 3032078. PMID 20560210.

Further reading

• D'Souza SS, Fazleabas AT, Banerjee P, et al. (2008). "Decidual heparanase activity is increased during pregnancy in the baboon (Papio anubis) and in in vitro decidualization of human stromal cells". Biol. Reprod. 78 (2): 316–23. doi:10.1095/biolreprod.107.063891. PMID 17989358.
• Bar-Sela G, Kaplan-Cohen V, Ilan N, et al. (2006). "Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival". Histopathology. 49 (2): 188–93. doi:10.1111/j.1365-2559.2006.02469.x. PMID 16879396.
• Beckhove P, Helmke BM, Ziouta Y, et al. (2005). "Heparanase expression at the invasion front of human head and neck cancers and correlation with poor prognosis". Clin. Cancer Res. 11 (8): 2899–906. doi:10.1158/1078-0432.CCR-04-0664. PMID 15837740.
• Ogishima T, Shiina H, Breault JE, et al. (2005). "Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer". Clin. Cancer Res. 11 (3): 1028–36. PMID 15709168.
• Wang Z, Xu H, Jiang L, et al. (2005). "Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma". Mod. Pathol. 18 (2): 205–11. doi:10.1038/modpathol.3800282. PMID 15475937.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.