NEU2

Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.[5][6][7]

NEU2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SNT, 1SO7, 1VCU, 2F0Z, 2F10, 2F11, 2F12, 2F13, 2F24, 2F25, 2F26, 2F27, 2F28, 2F29, 4NC5, 4NCS
Identifiers
Aliases	NEU2, SIAL2, neuraminidase 2 (cytosolic sialidase), neuraminidase 2
External IDs	OMIM: 605528 MGI: 1344417 HomoloGene: 3927 GeneCards: NEU2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 233,032,672 bp[1] End 233,035,057 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 87,509,889 bp[2] End 87,597,845 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • exo-alpha-(2->6)-sialidase activity • exo-alpha-(2->8)-sialidase activity • hydrolase activity, acting on glycosyl bonds • GO:0001948 protein binding • exo-alpha-(2->3)-sialidase activity • hydrolase activity • exo-alpha-sialidase activity Cellular component • cytoplasm • membrane • intracellular membrane-bounded organelle • cytosol • catalytic complex Biological process • glycosphingolipid metabolic process • lipid metabolism • lipid catabolic process • oligosaccharide catabolic process • metabolism • ganglioside catabolic process • cellular oligosaccharide catabolic process • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4759	23956
Ensembl	ENSG00000115488	ENSMUSG00000079434
UniProt	Q9Y3R4	Q9JMH3
RefSeq (mRNA)	NM_005383	NM_001160163 NM_001160164 NM_001160165 NM_015750
RefSeq (protein)	NP_005374	NP_001153635 NP_001153636 NP_001153637 NP_056565
Location (UCSC)	Chr 2: 233.03 – 233.04 Mb	Chr 1: 87.51 – 87.6 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000115488 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000079434 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Monti E, Preti A, Rossi E, Ballabio A, Borsani G (Jun 1999). "Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases". Genomics. 57 (1): 137–143. doi:10.1006/geno.1999.5749. PMID 10191093.
6. Tringali C, Papini N, Fusi P, Croci G, Borsani G, Preti A, Tortora P, Tettamanti G, Venerando B, Monti E (Jan 2004). "Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules". J Biol Chem. 279 (5): 3169–3179. doi:10.1074/jbc.M308381200. PMID 14613940.
7. "Entrez Gene: NEU2 sialidase 2 (cytosolic sialidase)".

Further reading

• Li CY, Yu Q, Ye ZQ, et al. (2007). "A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir". Cell Res. 17 (4): 357–362. doi:10.1038/cr.2007.27. PMID 17426694.
• Chavas LM, Tringali C, Fusi P, et al. (2005). "Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition". J. Biol. Chem. 280 (1): 469–75. doi:10.1074/jbc.M411506200. PMID 15501818.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hart ML, Saifuddin M, Uemura K, et al. (2003). "High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1". AIDS Res. Hum. Retroviruses. 18 (17): 1311–1317. doi:10.1089/088922202320886352. PMID 12487819.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bassi MT, Sperandeo MP, Incerti B, et al. (2000). "SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family". Genomics. 62 (2): 297–303. doi:10.1006/geno.1999.5978. PMID 10610726.
• Monti E, Preti A, Nesti C, et al. (2000). "Expression of a novel human sialidase encoded by the NEU2 gene". Glycobiology. 9 (12): 1313–1321. doi:10.1093/glycob/9.12.1313. PMID 10561456.
• Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–70. doi:10.1128/JVI.70.11.7462-7470.1996. PMC 190813. PMID 8892864.
• Miyagi T, Konno K, Emori Y, et al. (1994). "Molecular cloning and expression of cDNA encoding rat skeletal muscle cytosolic sialidase". J. Biol. Chem. 268 (35): 26435–40. PMID 8253770.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Sialidase-2