UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing)

UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing) (EC 3.2.1.184, UDP-Bac2Ac4Ac 2-epimerase, NeuC) is an enzyme with systematic name UDP-N,N'-diacetylbacillosamine hydrolase (2-epimerising).[1][2] This enzyme catalyses the following chemical reaction

UDP-N,N'-diacetylbacillosamine + H2O UDP + 2,4-diacetamido-2,4,6-trideoxy-D-mannopyranose
UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing)
Identifiers
EC number3.2.1.184
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme requires Mg2+. It is involved in biosynthesis of legionaminic acid.

References

  1. Glaze PA, Watson DC, Young NM, Tanner ME (March 2008). "Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila". Biochemistry. 47 (10): 3272–82. doi:10.1021/bi702364s. PMID 18275154.
  2. Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM (July 2009). "The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors". Glycobiology. 19 (7): 715–25. doi:10.1093/glycob/cwp039. PMID 19282391.
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