UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase

UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase (EC 3.6.1.57, PseG, UDP-6-deoxy-AltdiNAc hydrolase, Cj1312) is an enzyme with systematic name UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose hydrolase.[1][2] This enzyme catalyses the following chemical reaction

UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose + H2O 2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose + UDP
UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase
Identifiers
EC number3.6.1.57
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme is involved in biosynthesis of pseudaminic acid.

References

  1. Liu F, Tanner ME (July 2006). "PseG of pseudaminic acid biosynthesis: a UDP-sugar hydrolase as a masked glycosyltransferase". The Journal of Biological Chemistry. 281 (30): 20902–9. doi:10.1074/jbc.m602972200. PMID 16728396.
  2. Schoenhofen IC, McNally DJ, Brisson JR, Logan SM (September 2006). "Elucidation of the CMP-pseudaminic acid pathway in Helicobacter pylori: synthesis from UDP-N-acetylglucosamine by a single enzymatic reaction". Glycobiology. 16 (9): 8C–14C. doi:10.1093/glycob/cwl010. PMID 16751642.
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