Ribonuclease 4

Ribonuclease 4 is an enzyme that in humans is encoded by the RNASE4 gene.[5][6]

RNASE4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RNF, 2RNF
Identifiers
Aliases	RNASE4, RAB1, RNS4, Ribonuclease 4, ribonuclease A family member 4
External IDs	OMIM: 601030 MGI: 1926217 HomoloGene: 10576 GeneCards: RNASE4
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 20,684,560 bp[1] End 20,701,216 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 51,091,077 bp[2] End 51,106,151 bp[2]
Gene ontology Molecular function • nuclease activity • endonuclease activity • ribonuclease activity • hydrolase activity • ribonuclease A activity • nucleic acid binding Cellular component • extracellular region Biological process • mRNA cleavage • RNA phosphodiester bond hydrolysis, endonucleolytic Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6038	58809
Ensembl	ENSG00000258818	ENSMUSG00000021876
UniProt	P34096	Q9JJH1 Q8C7E4
RefSeq (mRNA)	NM_194431 NM_001282192 NM_001282193 NM_002937 NM_194430	NM_021472 NM_201239
RefSeq (protein)	NP_001269121 NP_001269122 NP_002928 NP_919412	NP_067447 NP_957691
Location (UCSC)	Chr 14: 20.68 – 20.7 Mb	Chr 14: 51.09 – 51.11 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides.

Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000258818 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021876 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rosenberg HF, Dyer KD (Jan 1996). "Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues". Nucleic Acids Res. 23 (21): 4290–5. doi:10.1093/nar/23.21.4290. PMC 307382. PMID 7501448.
6. "Entrez Gene: RNASE4 ribonuclease, RNase A family, 4".

Further reading

• Shapiro R, Fett JW, Strydom DJ, Vallee BL (1987). "Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity". Biochemistry. 25 (23): 7255–64. doi:10.1021/bi00371a002. PMID 3467790.
• Seno M, Futami J, Tsushima Y, et al. (1995). "Molecular cloning and expression of human ribonuclease 4 cDNA". Biochim. Biophys. Acta. 1261 (3): 424–6. doi:10.1016/0167-4781(95)00040-n. PMID 7742370.
• Zhou HM, Strydom DJ (1993). "The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine". Eur. J. Biochem. 217 (1): 401–10. doi:10.1111/j.1432-1033.1993.tb18259.x. PMID 8223579.
• Egesten A, Dyer KD, Batten D, et al. (1997). "Ribonucleases and host defense: identification, localization and gene expression in adherent monocytes in vitro". Biochim. Biophys. Acta. 1358 (3): 255–60. doi:10.1016/S0167-4889(97)00081-5. PMID 9366257.
• Terzyan SS, Peracaula R, de Llorens R, et al. (1999). "The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity". J. Mol. Biol. 285 (1): 205–14. doi:10.1006/jmbi.1998.2288. PMID 9878400.
• Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.