Rhamnogalacturonan rhamnohydrolase

Rhamnogalacturonan rhamnohydrolase (EC 3.2.1.174, RG-rhamnohydrolase, RG alpha-L-rhamnopyranohydrolase) is an enzyme with systematic name rhamnogalacturonan oligosaccharide alpha-L-Rha-(1->4)-alpha-D-GalA rhamnohydrolase.[1][2] This enzyme catalyses the following chemical reaction

Exohydrolysis of the alpha-L-Rha-(1->4)-alpha-D-GalA bond in rhamnogalacturonan oligosaccharides with initial inversion of configuration releasing beta-L-rhamnose from the non-reducing end of rhamnogalacturonan oligosaccharides.
Rhamnogalacturonan rhamnohydrolase
Identifiers
EC number3.2.1.174
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme is part of the degradation system for rhamnogalacturonan I in Aspergillus aculeatus.

References

  1. Pitson SM, Mutter M, van den Broek LA, Voragen AG, Beldman G (January 1998). "Stereochemical course of hydrolysis catalysed by alpha-L-rhamnosyl and alpha-D-galacturonosyl hydrolases from Aspergillus aculeatus". Biochemical and Biophysical Research Communications. 242 (3): 552–9. doi:10.1006/bbrc.1997.8009. PMID 9464254.
  2. Mutter M, Beldman G, Schols HA, Voragen AG (September 1994). "Rhamnogalacturonan alpha-L-rhamnopyranohydrolase. A novel enzyme specific for the terminal nonreducing rhamnosyl unit in rhamnogalacturonan regions of pectin". Plant Physiology. 106 (1): 241–50. doi:10.1104/pp.106.1.241. PMC 159522. PMID 7972516.
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