Pimelyl-(acyl-carrier protein) methyl ester esterase
Pimelyl-(acyl-carrier protein) methyl ester esterase (EC 3.1.1.85, BioH) is an enzyme with systematic name pimelyl-(acyl-carrier protein) methyl ester hydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- pimelyl-[acyl-carrier protein] methyl ester + H2O pimelyl-[acyl-carrier protein] + methanol
| Pimelyl-(acyl-carrier protein) methyl ester esterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.1.85 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme takes part in biotin biosynthesis in Gram-negative bacteria.
References
- Sanishvili R, Yakunin AF, Laskowski RA, Skarina T, Evdokimova E, Doherty-Kirby A, Lajoie GA, Thornton JM, Arrowsmith CH, Savchenko A, Joachimiak A, Edwards AM (July 2003). "Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli". The Journal of Biological Chemistry. 278 (28): 26039–45. doi:10.1074/jbc.M303867200. PMC 2792009. PMID 12732651.
- Lemoine Y, Wach A, Jeltsch JM (February 1996). "To be free or not: the fate of pimelate in Bacillus sphaericus and in Escherichia coli". Molecular Microbiology. 19 (3): 645–7. doi:10.1046/j.1365-2958.1996.t01-4-442924.x. PMID 8830257.
- Tomczyk NH, Nettleship JE, Baxter RL, Crichton HJ, Webster SP, Campopiano DJ (February 2002). "Purification and characterisation of the BIOH protein from the biotin biosynthetic pathway". FEBS Letters. 513 (2–3): 299–304. doi:10.1016/s0014-5793(02)02342-6. PMID 11904168.
- Lin S, Hanson RE, Cronan JE (September 2010). "Biotin synthesis begins by hijacking the fatty acid synthetic pathway". Nature Chemical Biology. 6 (9): 682–8. doi:10.1038/nchembio.420. PMC 2925990. PMID 20693992.
External links
- Pimelyl-(acyl-carrier+protein)+methyl+ester+esterase at the US National Library of Medicine Medical Subject Headings (MeSH)
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